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    Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score.

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    37
    Author
    Lim, YY; Snyder, PJ; Pietrzak, RH; Ukiqi, A; Villemagne, VL; Ames, D; Salvado, O; Bourgeat, P; Martins, RN; Masters, CL; ...
    Date
    2016
    Source Title
    Alzheimer's & dementia (Amsterdam, Netherlands)
    Publisher
    Wiley
    University of Melbourne Author/s
    Ames, David; Rowe, Christopher; Masters, Colin; Maruff, Paul; Lim, Yen Ying; Villemagne, Victor
    Affiliation
    Anatomy and Neuroscience
    Florey Department of Neuroscience and Mental Health
    Psychiatry
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Lim, Y. Y., Snyder, P. J., Pietrzak, R. H., Ukiqi, A., Villemagne, V. L., Ames, D., Salvado, O., Bourgeat, P., Martins, R. N., Masters, C. L., Rowe, C. C. & Maruff, P. (2016). Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score.. Alzheimers Dement (Amst), 2 (1), pp.19-26. https://doi.org/10.1016/j.dadm.2015.11.003.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260476
    DOI
    10.1016/j.dadm.2015.11.003
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879646
    Abstract
    INTRODUCTION: Cognitive composite scores developed for preclinical Alzheimer's disease (AD) often consist of multiple cognitive domains as they may provide greater sensitivity to detect β-amyloid (Aβ)-related cognitive decline than episodic memory (EM) composite scores alone. However, this has never been empirically tested. We compared the rate of cognitive decline associated with high Aβ (Aβ+) and very high Aβ (Aβ++) in cognitively normal (CN) older adults on three multidomain cognitive composite scores and one single-domain (EM) composite score. METHODS: CN older adults (n = 423) underwent Aβ neuroimaging and completed neuropsychological assessments at baseline, and at 18-, 36-, 54-, and 72-month follow-ups. Four cognitive composite scores were computed: the ADCS-PACC (ADCS-Preclinical Alzheimer Cognitive Composite), ADCS-PACC without the inclusion of the mini-mental state examination (MMSE), an EM composite, and the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults (ZAVEN) composite. RESULTS: Compared with Aβ+ CN older adults, Aβ++ CN older adults showed faster rates of decline across all cognitive composites, with the largest decline observed for ZAVEN composite (d = 1.07). Similarly, compared with Aβ- CN older adults, Aβ+ CN older adults also showed faster rates of cognitive decline, but only for the ADCS-PACC no MMSE (d = 0.43), EM (d = 0.53), and ZAVEN (d = 0.50) composites. DISCUSSION: Aβ-related cognitive decline is best detected using validated neuropsychological instruments. Removal of the MMSE from the ADCS-PACC and replacing it with a test of executive function (verbal fluency; i.e., the ZAVEN) rendered this composite more sensitive even in detecting Aβ-related cognitive decline between Aβ+ and Aβ++ CN older adults.

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