Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia

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Ng, ALK; Chan, TCY; Cheng, GPM; Jhanji, V; Ye, C; Woo, VCP; Lai, JSMDate
2016-01-01Source Title
Journal of OphthalmologyPublisher
HINDAWI LTDUniversity of Melbourne Author/s
Jhanji, VishalAffiliation
Ophthalmology (Eye & Ear Hospital)Metadata
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Journal ArticleCitations
Ng, A. L. K., Chan, T. C. Y., Cheng, G. P. M., Jhanji, V., Ye, C., Woo, V. C. P. & Lai, J. S. M. (2016). Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia. JOURNAL OF OPHTHALMOLOGY, 2016, https://doi.org/10.1155/2016/2672980.Access Status
Open AccessAbstract
Background. To compare the early outcome of combined SMILE and collagen crosslinking (SMILE Xtra) with SMILE. Method. Prospective, comparative interventional study of 21 eyes receiving SMILE Xtra using a low energy protocol and 32 control eyes receiving SMILE only. The outcomes were compared at 1, 3, and 6 months postoperatively. Results. Both groups had myopia with spherical equivalent refraction (SEQ) > 4.00 D. The SMILE Xtra group had thinner preoperative central corneal thickness and residual stromal bed thickness (p < 0.021). At 6 months, no eyes lost more than 1 line in corrected distance visual acuity. The safety index was 0.96 ± 0.06 and 1.00 ± 0.00 in SMILE Xtra and control, respectively (p < 0.001). 89% and 94% of eyes were within ±0.50 D of target refraction, respectively, with the mean error in SEQ correction being -0.17 ± 0.26 D for SMILE Xtra and +0.03 ± 0.25 D for control (p = 0.021). The efficacy index was 0.88 ± 0.13 and 0.97 ± 0.06, respectively (p = 0.005). Conclusion. SMILE Xtra had good overall safety profile and predictability at 6 months. However, when compared with control, the safety index and efficacy index were statistically significantly lower in the early postoperative period.
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