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dc.contributor.authorNatoli, R
dc.contributor.authorValter, K
dc.contributor.authorBarbosa, M
dc.contributor.authorDahlstrom, J
dc.contributor.authorRutar, M
dc.contributor.authorKent, A
dc.contributor.authorProvis, J
dc.date.accessioned2021-02-12T00:18:24Z
dc.date.available2021-02-12T00:18:24Z
dc.date.issued2013-08-08
dc.identifierpii: PONE-D-13-15663
dc.identifier.citationNatoli, R., Valter, K., Barbosa, M., Dahlstrom, J., Rutar, M., Kent, A. & Provis, J. (2013). 670nm Photobiomodulation as a Novel Protection against Retinopathy of Prematurity: Evidence from Oxygen Induced Retinopathy Models. PLOS ONE, 8 (8), https://doi.org/10.1371/journal.pone.0072135.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/260533
dc.description.abstractINTRODUCTION: To investigate the validity of using 670nm red light as a preventative treatment for Retinopathy of Prematurity in two animal models of oxygen-induced retinopathy (OIR). MATERIALS AND METHODS: During and post exposure to hyperoxia, C57BL/6J mice or Sprague-Dawley rats were exposed to 670 nm light for 3 minutes a day (9J/cm²). Whole mounted retinas were investigated for evidence of vascular abnormalities, while sections of neural retina were used to quantify levels of cell death using the TUNEL technique. Organs were removed, weighed and independent histopathology examination performed. RESULTS: 670 nm light reduced neovascularisation, vaso-obliteration and abnormal peripheral branching patterns of retinal vessels in OIR. The neural retina was also protected against OIR by 670 nm light exposure. OIR-exposed animals had severe lung pathology, including haemorrhage and oedema, that was significantly reduced in 670 nm+OIR light-exposed animals. There were no significance differences in the organ weights of animals in the 670 nm light-exposed animals, and no adverse effects of exposure to 670 nm light were detected. DISCUSSION: Low levels of exposure to 670 nm light protects against OIR and lung damage associated with exposure to high levels of oxygen, and may prove to be a non-invasive and inexpensive preventative treatment for ROP and chronic lung disease associated with prematurity.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.title670nm Photobiomodulation as a Novel Protection against Retinopathy of Prematurity: Evidence from Oxygen Induced Retinopathy Models
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0072135
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS One
melbourne.source.volume8
melbourne.source.issue8
dc.rights.licenseCC BY
melbourne.elementsid1110034
melbourne.contributor.authorRutar, Matthew
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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