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    Glucose metabolism regulatesT cell activation, differentiation, and functions

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    157
    Author
    Palmer, CS; Ostrowski, M; Balderson, B; Christian, N; Crowe, SM
    Date
    2015-01-22
    Source Title
    Frontiers in Immunology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Palmer, Clovis
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Palmer, C. S., Ostrowski, M., Balderson, B., Christian, N. & Crowe, S. M. (2015). Glucose metabolism regulatesT cell activation, differentiation, and functions. FRONTIERS IN IMMUNOLOGY, 6 (JAN), https://doi.org/10.3389/fimmu.2015.00001.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260536
    DOI
    10.3389/fimmu.2015.00001
    Abstract
    The adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate T cell subsets. It is now established that changes in cellular activation are coupled to profound changes in cellular metabolism. In addition, emerging evidence now suggest that specific metabolic alterations associated with distinct T cell subsets may be ancillary to their differentiation and influential in their immune functions. The "Warburg effect" originally used to describe a phenomenon in which most cancer cells relied on aerobic glycolysis for their growth is a key process that sustain T cell activation and differentiation. Here, we review how different aspects of metabolism in T cells influence their functions, focusing on the emerging role of key regulators of glucose metabolism such as HIF-1α. A thorough understanding of the role of metabolism in T cell function could provide insights into mechanisms involved in inflammatory-mediated conditions, with the potential for developing novel therapeutic approaches to treat these diseases.

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