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dc.contributor.authorPalmer, CS
dc.contributor.authorOstrowski, M
dc.contributor.authorBalderson, B
dc.contributor.authorChristian, N
dc.contributor.authorCrowe, SM
dc.date.accessioned2021-02-12T00:18:44Z
dc.date.available2021-02-12T00:18:44Z
dc.date.issued2015-01-22
dc.identifier.citationPalmer, C. S., Ostrowski, M., Balderson, B., Christian, N. & Crowe, S. M. (2015). Glucose metabolism regulatesT cell activation, differentiation, and functions. FRONTIERS IN IMMUNOLOGY, 6 (JAN), https://doi.org/10.3389/fimmu.2015.00001.
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/11343/260536
dc.description.abstractThe adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate T cell subsets. It is now established that changes in cellular activation are coupled to profound changes in cellular metabolism. In addition, emerging evidence now suggest that specific metabolic alterations associated with distinct T cell subsets may be ancillary to their differentiation and influential in their immune functions. The "Warburg effect" originally used to describe a phenomenon in which most cancer cells relied on aerobic glycolysis for their growth is a key process that sustain T cell activation and differentiation. Here, we review how different aspects of metabolism in T cells influence their functions, focusing on the emerging role of key regulators of glucose metabolism such as HIF-1α. A thorough understanding of the role of metabolism in T cell function could provide insights into mechanisms involved in inflammatory-mediated conditions, with the potential for developing novel therapeutic approaches to treat these diseases.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGlucose metabolism regulatesT cell activation, differentiation, and functions
dc.typeJournal Article
dc.identifier.doi10.3389/fimmu.2015.00001
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Immunology
melbourne.source.volume6
melbourne.source.issueJAN
dc.rights.licenseCC BY
melbourne.elementsid1110100
melbourne.contributor.authorPalmer, Clovis
dc.identifier.eissn1664-3224
melbourne.accessrightsOpen Access


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