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dc.contributor.authorSnyder, PJ
dc.contributor.authorJohnson, LN
dc.contributor.authorLim, YY
dc.contributor.authorSantos, CY
dc.contributor.authorAlber, J
dc.contributor.authorMaruff, P
dc.contributor.authorFernández, B
dc.date.accessioned2021-02-12T00:19:20Z
dc.date.available2021-02-12T00:19:20Z
dc.date.issued2016
dc.identifierpii: S2352-8729(16)30046-X
dc.identifier.citationSnyder, P. J., Johnson, L. N., Lim, Y. Y., Santos, C. Y., Alber, J., Maruff, P. & Fernández, B. (2016). Nonvascular retinal imaging markers of preclinical Alzheimer's disease.. Alzheimers Dement (Amst), 4 (1), pp.169-178. https://doi.org/10.1016/j.dadm.2016.09.001.
dc.identifier.issn2352-8729
dc.identifier.urihttp://hdl.handle.net/11343/260541
dc.description.abstractINTRODUCTION: In patients with Alzheimer's disease (AD) and mild cognitive impairment, structural changes in the retina (i.e., reduced thicknesses of the ganglion cell and retinal nerve fiber layers and inclusion bodies that appear to contain beta-amyloid protein [Ab]) have been previously reported. We sought to explore whether anatomic retinal changes are detectable in the preclinical stage of AD. METHODS: A cross-sectional study (as part of an ongoing longitudinal cohort study) involving 63 cognitively normal adults, all of whom have a parent with AD and subjective memory complaints. We compared neocortical amyloid aggregation (florbetapir PET imaging) to retinal spectral domain optical coherence tomography (SD-OCT) markers of possible disease burden. Retinal biomarkers, including the number and surface area of retinal inclusion bodies and the thickness of retinal neuronal layers, were compared across groups with high vs. low neocortical beta-amyloid load. RESULTS: The surface area of inclusion bodies increased as a function of cortical amyloid burden. Additionally, there was a trend toward a selective volume increase in the inner plexiform layer (IPL; a layer rich in cholinergic activity) of the retina in Aβ+ relative to Aβ- participants, and IPL volume was correlated with the surface area of retinal inclusion bodies. DISCUSSION: These initial results suggest that retinal imaging may be a potential cost-effective and noninvasive technique that can be used to identify those at-risk for AD. Layer-specific changes in the IPL and their association with surface area of inclusion bodies are discussed as a possible reflection of early inflammatory processes associated with cholinergic disruption and concurrent Ab accumulation in the neocortex.
dc.languageeng
dc.publisherWiley
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleNonvascular retinal imaging markers of preclinical Alzheimer's disease.
dc.typeJournal Article
dc.identifier.doi10.1016/j.dadm.2016.09.001
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
melbourne.source.volume4
melbourne.source.issue1
melbourne.source.pages169-178
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1111689
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078641
melbourne.contributor.authorMaruff, Paul
melbourne.contributor.authorLim, Yen Ying
dc.identifier.eissn2352-8729
melbourne.accessrightsOpen Access


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