Targeting dendritic cells: a promising strategy to improve vaccine effectiveness

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    Author
    Macri, C; Dumont, C; Johnston, APR; Mintern, JD
    Date
    2016-03-01
    Source Title
    Clinical & Translational Immunology
    Publisher
    WILEY
    University of Melbourne Author/s
    Mintern, Justine; DUMONT, CLAIRE; Macri, Christophe
    Affiliation
    Biochemistry and Molecular Biology
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    Document Type
    Journal Article
    Citations
    Macri, C., Dumont, C., Johnston, A. P. R. & Mintern, J. D. (2016). Targeting dendritic cells: a promising strategy to improve vaccine effectiveness. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 5 (3), https://doi.org/10.1038/cti.2016.6.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260549
    DOI
    10.1038/cti.2016.6
    Abstract
    Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of DCs. Here we review the complexity of the DC subsets and the antigen presentation pathways that need to be considered in the settings of DC targeting. We also summarize current knowledge about antigen delivery to DCs via DEC-205, Clec9A and Clec12A, receptor targets that strongly enhance cellular and humoral immune responses. Finally, we discuss the intracellular trafficking criteria of the targeted receptors that may impact their effectiveness as DC targets.

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