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dc.contributor.authorMah, L-J
dc.contributor.authorOrlowski, C
dc.contributor.authorVerveris, K
dc.contributor.authorVasireddy, RS
dc.contributor.authorEl-Osta, A
dc.contributor.authorKaragiannis, TC
dc.date.accessioned2021-02-12T00:24:24Z
dc.date.available2021-02-12T00:24:24Z
dc.date.issued2011-01-25
dc.identifierpii: 2041-9414-2-3
dc.identifier.citationMah, L. -J., Orlowski, C., Ververis, K., Vasireddy, R. S., El-Osta, A. & Karagiannis, T. C. (2011). Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.. Genome Integr, 2 (1), pp.3-. https://doi.org/10.1186/2041-9414-2-3.
dc.identifier.issn2041-9414
dc.identifier.urihttp://hdl.handle.net/11343/260584
dc.description.abstractRadiation therapy is a widely used therapeutic approach for cancer. To improve the efficacy of radiotherapy there is an intense interest in combining this modality with two broad classes of compounds, radiosensitizers and radioprotectors. These either enhance tumour-killing efficacy or mitigate damage to surrounding non-malignant tissue, respectively. Radiation exposure often results in the formation of DNA double-strand breaks, which are marked by the induction of H2AX phosphorylation to generate γH2AX. In addition to its essential role in DDR signalling and coordination of double-strand break repair, the ability to visualize and quantitate γH2AX foci using immunofluorescence microscopy techniques enables it to be exploited as an indicator of therapeutic efficacy in a range of cell types and tissues. This review will explore the emerging applicability of γH2AX as a marker for monitoring the effectiveness of radiation-modifying compounds.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEvaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.
dc.typeJournal Article
dc.identifier.doi10.1186/2041-9414-2-3
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleGenome Integrity
melbourne.source.volume2
melbourne.source.issue1
melbourne.source.pages3-
melbourne.identifier.nhmrc566559
dc.rights.licenseCC BY
melbourne.elementsid1071536
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037297
melbourne.contributor.authorEl-Osta, Assam
dc.identifier.eissn2041-9414
melbourne.identifier.fundernameidNHMRC, 566559
melbourne.accessrightsOpen Access


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