Flicking the molecular switch underlying MLKL-mediated necroptosis

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    Author
    Hildebrand, JM; Lucet, IS; Murphy, JM
    Date
    2015-01-01
    Source Title
    Molecular & cellular oncology
    Publisher
    TAYLOR & FRANCIS INC
    University of Melbourne Author/s
    Lucet, Isabelle; Hildebrand, Joanne; Murphy, James
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Hildebrand, J. M., Lucet, I. S. & Murphy, J. M. (2015). Flicking the molecular switch underlying MLKL-mediated necroptosis. MOLECULAR & CELLULAR ONCOLOGY, 2 (3), https://doi.org/10.4161/23723556.2014.985550.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/260592
    DOI
    10.4161/23723556.2014.985550
    Abstract
    The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL.

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