Flicking the molecular switch underlying MLKL-mediated necroptosis

Download
Author
Hildebrand, JM; Lucet, IS; Murphy, JMDate
2015-01-01Source Title
Molecular & cellular oncologyPublisher
TAYLOR & FRANCIS INCAffiliation
Medical Biology (W.E.H.I.)Metadata
Show full item recordDocument Type
Journal ArticleCitations
Hildebrand, J. M., Lucet, I. S. & Murphy, J. M. (2015). Flicking the molecular switch underlying MLKL-mediated necroptosis. MOLECULAR & CELLULAR ONCOLOGY, 2 (3), https://doi.org/10.4161/23723556.2014.985550.Access Status
Open AccessAbstract
The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References
Collections
- Minerva Elements Records [53039]
- Medical Biology - Research Publications [1415]