Flicking the molecular switch underlying MLKL-mediated necroptosis
AuthorHildebrand, JM; Lucet, IS; Murphy, JM
Source TitleMolecular & cellular oncology
PublisherTAYLOR & FRANCIS INC
AffiliationMedical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsHildebrand, J. M., Lucet, I. S. & Murphy, J. M. (2015). Flicking the molecular switch underlying MLKL-mediated necroptosis. MOLECULAR & CELLULAR ONCOLOGY, 2 (3), https://doi.org/10.4161/23723556.2014.985550.
Access StatusOpen Access
The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL.
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