| dc.contributor.author | Hildebrand, JM | |
| dc.contributor.author | Lucet, IS | |
| dc.contributor.author | Murphy, JM | |
| dc.date.accessioned | 2021-02-12T00:25:23Z | |
| dc.date.available | 2021-02-12T00:25:23Z | |
| dc.date.issued | 2015-01-01 | |
| dc.identifier | pii: 985550 | |
| dc.identifier.citation | Hildebrand, J. M., Lucet, I. S. & Murphy, J. M. (2015). Flicking the molecular switch underlying MLKL-mediated necroptosis. MOLECULAR & CELLULAR ONCOLOGY, 2 (3), https://doi.org/10.4161/23723556.2014.985550. | |
| dc.identifier.issn | 2372-3556 | |
| dc.identifier.uri | http://hdl.handle.net/11343/260592 | |
| dc.description.abstract | The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL. | |
| dc.language | English | |
| dc.publisher | TAYLOR & FRANCIS INC | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
| dc.title | Flicking the molecular switch underlying MLKL-mediated necroptosis | |
| dc.type | Journal Article | |
| dc.identifier.doi | 10.4161/23723556.2014.985550 | |
| melbourne.affiliation.department | Medical Biology (W.E.H.I.) | |
| melbourne.affiliation.faculty | Medicine, Dentistry & Health Sciences | |
| melbourne.source.title | Molecular and Cellular Oncology | |
| melbourne.source.volume | 2 | |
| melbourne.source.issue | 3 | |
| dc.rights.license | CC BY-NC | |
| melbourne.elementsid | 1072918 | |
| melbourne.contributor.author | Lucet, Isabelle | |
| melbourne.contributor.author | Hildebrand, Joanne | |
| melbourne.contributor.author | Murphy, James | |
| dc.identifier.eissn | 2372-3548 | |
| melbourne.accessrights | Open Access | |
