The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4.
AuthorSeo, J-S; Chong, H; Park, HS; Yoon, K-O; Jung, C; Kim, JJ; Hong, JH; Kim, H; Kim, J-H; Kil, J-I; ...
Source TitleNature Biotechnology
PublisherSpringer Science and Business Media LLC
University of Melbourne Author/sJung, Chol-Hee
AffiliationMedicine Dentistry & Health Sciences
Document TypeJournal Article
CitationsSeo, J. -S., Chong, H., Park, H. S., Yoon, K. -O., Jung, C., Kim, J. J., Hong, J. H., Kim, H., Kim, J. -H., Kil, J. -I., Park, C. J., Oh, H. -M., Lee, J. -S., Jin, S. -J., Um, H. -W., Lee, H. -J., Oh, S. -J., Kim, J. Y., Kang, H. L. ,... Kang, H. S. (2005). The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4.. Nat Biotechnol, 23 (1), pp.63-68. https://doi.org/10.1038/nbt1045.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6870993
We report the complete genome sequence of Zymomonas mobilis ZM4 (ATCC31821), an ethanologenic microorganism of interest for the production of fuel ethanol. The genome consists of 2,056,416 base pairs forming a circular chromosome with 1,998 open reading frames (ORFs) and three ribosomal RNA transcription units. The genome lacks recognizable genes for 6-phosphofructokinase, an essential enzyme in the Embden-Meyerhof-Parnas pathway, and for two enzymes in the tricarboxylic acid cycle, the 2-oxoglutarate dehydrogenase complex and malate dehydrogenase, so glucose can be metabolized only by the Entner-Doudoroff pathway. Whole genome microarrays were used for genomic comparisons with the Z. mobilis type strain ZM1 (ATCC10988) revealing that 54 ORFs predicted to encode for transport and secretory proteins, transcriptional regulators and oxidoreductase in the ZM4 strain were absent from ZM1. Most of these ORFs were also found to be actively transcribed in association with ethanol production by ZM4.
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