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dc.contributor.authorHunt, NH
dc.contributor.authorBall, HJ
dc.contributor.authorHansen, AM
dc.contributor.authorKhaw, LT
dc.contributor.authorGuo, J
dc.contributor.authorBakmiwewa, S
dc.contributor.authorMitchell, AJ
dc.contributor.authorCombes, V
dc.contributor.authorGrau, GER
dc.date.accessioned2021-02-12T00:29:09Z
dc.date.available2021-02-12T00:29:09Z
dc.date.issued2014-08-01
dc.identifier.citationHunt, N. H., Ball, H. J., Hansen, A. M., Khaw, L. T., Guo, J., Bakmiwewa, S., Mitchell, A. J., Combes, V. & Grau, G. E. R. (2014). Cerebral malaria: gamma-interferon redux. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 4 (AUG), https://doi.org/10.3389/fcimb.2014.00113.
dc.identifier.issn2235-2988
dc.identifier.urihttp://hdl.handle.net/11343/260625
dc.description.abstractThere are two theories that seek to explain the pathogenesis of cerebral malaria, the mechanical obstruction hypothesis and the immunopathology hypothesis. Evidence consistent with both ideas has accumulated from studies of the human disease and experimental models. Thus, some combination of these concepts seems necessary to explain the very complex pattern of changes seen in cerebral malaria. The interactions between malaria parasites, erythrocytes, the cerebral microvascular endothelium, brain parenchymal cells, platelets and microparticles need to be considered. One factor that seems able to knit together much of this complexity is the cytokine interferon-gamma (IFN-γ). In this review we consider findings from the clinical disease, in vitro models and the murine counterpart of human cerebral malaria in order to evaluate the roles played by IFN-γ in the pathogenesis of this often fatal and debilitating condition.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleCerebral malaria: gamma-interferon redux
dc.typeJournal Article
dc.identifier.doi10.3389/fcimb.2014.00113
melbourne.affiliation.departmentChemical and Biomolecular Engineering
melbourne.affiliation.facultyEngineering and Information Technology
melbourne.source.titleFrontiers in Cellular and Infection Microbiology
melbourne.source.volume4
melbourne.source.issueAUG
dc.rights.licenseCC BY
melbourne.elementsid1079634
melbourne.contributor.authorMitchell, Andrew
dc.identifier.eissn2235-2988
melbourne.accessrightsOpen Access


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