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dc.contributor.authorBeavitt, SJE
dc.contributor.authorHarder, KW
dc.contributor.authorKemp, JM
dc.contributor.authorJones, J
dc.contributor.authorQuilici, C
dc.contributor.authorCasagranda, F
dc.contributor.authorLam, E
dc.contributor.authorTurner, D
dc.contributor.authorBrennan, S
dc.contributor.authorSly, PD
dc.contributor.authorTarlinton, DM
dc.contributor.authorAnderson, GP
dc.contributor.authorHibbs, ML
dc.identifierpii: 175/3/1867
dc.identifier.citationBeavitt, S. J. E., Harder, K. W., Kemp, J. M., Jones, J., Quilici, C., Casagranda, F., Lam, E., Turner, D., Brennan, S., Sly, P. D., Tarlinton, D. M., Anderson, G. P. & Hibbs, M. L. (2005). Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. JOURNAL OF IMMUNOLOGY, 175 (3), pp.1867-1875.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe etiology of asthma, a chronic inflammatory disorder of the airways, remains obscure, although T cells appear to be central disease mediators. Lyn tyrosine kinase has been implicated as both a facilitator and inhibitor of signaling pathways that play a role in allergic inflammation, although its role in asthma is unclear because Lyn is not expressed in T cells. We show in the present study that Lyn-/- mice develop a severe, persistent inflammatory asthma-like syndrome with lung eosinophilia, mast cell hyperdegranulation, intensified bronchospasm, hyper IgE, and Th2-polarizing dendritic cells. Dendritic cells from Lyn-/- mice have a more immature phenotype, exhibit defective inhibitory signaling pathways, produce less IL-12, and can transfer disease when adoptively transferred into wild-type recipients. Our results show that Lyn regulates the intensity and duration of multiple asthmatic traits and indicate that Lyn is an important negative regulator of Th2 immune responses.
dc.subjectOncology and Carcinogenesis; Cancer and Related Disorders
dc.titleLyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentSurgery - Royal Melbourne And Western Hospital
melbourne.source.titleJournal of Immunology
melbourne.contributor.authorKEMP, JOANNA
melbourne.contributor.authorAnderson, Gary
melbourne.contributor.authorHIBBS, MARGARET
melbourne.contributor.authorBeavitt, Sarah-Jane
melbourne.contributor.authorHARDER, KENNETH
melbourne.accessrightsThis item is currently not available from this repository

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