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dc.contributor.authorBeavitt, SJE
dc.contributor.authorHarder, KW
dc.contributor.authorKemp, JM
dc.contributor.authorJones, J
dc.contributor.authorQuilici, C
dc.contributor.authorCasagranda, F
dc.contributor.authorLam, E
dc.contributor.authorTurner, D
dc.contributor.authorBrennan, S
dc.contributor.authorSly, PD
dc.contributor.authorTarlinton, DM
dc.contributor.authorAnderson, GP
dc.contributor.authorHibbs, ML
dc.date.available2014-05-21T19:20:04Z
dc.date.issued2005-08-01
dc.identifierpii: 175/3/1867
dc.identifier.citationBeavitt, S. J. E., Harder, K. W., Kemp, J. M., Jones, J., Quilici, C., Casagranda, F., Lam, E., Turner, D., Brennan, S., Sly, P. D., Tarlinton, D. M., Anderson, G. P. & Hibbs, M. L. (2005). Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. JOURNAL OF IMMUNOLOGY, 175 (3), pp.1867-1875. https://doi.org/10.4049/jimmunol.175.3.1867.
dc.identifier.issn0022-1767
dc.identifier.urihttp://hdl.handle.net/11343/26123
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe etiology of asthma, a chronic inflammatory disorder of the airways, remains obscure, although T cells appear to be central disease mediators. Lyn tyrosine kinase has been implicated as both a facilitator and inhibitor of signaling pathways that play a role in allergic inflammation, although its role in asthma is unclear because Lyn is not expressed in T cells. We show in the present study that Lyn-/- mice develop a severe, persistent inflammatory asthma-like syndrome with lung eosinophilia, mast cell hyperdegranulation, intensified bronchospasm, hyper IgE, and Th2-polarizing dendritic cells. Dendritic cells from Lyn-/- mice have a more immature phenotype, exhibit defective inhibitory signaling pathways, produce less IL-12, and can transfer disease when adoptively transferred into wild-type recipients. Our results show that Lyn regulates the intensity and duration of multiple asthmatic traits and indicate that Lyn is an important negative regulator of Th2 immune responses.
dc.languageEnglish
dc.publisherAMER ASSOC IMMUNOLOGISTS
dc.subjectOncology and Carcinogenesis; Cancer and Related Disorders
dc.titleLyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity
dc.typeJournal Article
dc.identifier.doi10.4049/jimmunol.175.3.1867
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentSurgery - Royal Melbourne And Western Hospital
melbourne.source.titleJournal of Immunology
melbourne.source.volume175
melbourne.source.issue3
melbourne.source.pages1867-1875
melbourne.publicationid39011
melbourne.elementsid269491
melbourne.contributor.authorKEMP, JOANNA
melbourne.contributor.authorAnderson, Gary
melbourne.contributor.authorHIBBS, MARGARET
melbourne.contributor.authorBeavitt, Sarah-Jane
melbourne.contributor.authorHARDER, KENNETH
dc.identifier.eissn1550-6606
melbourne.accessrightsThis item is currently not available from this repository


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