Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development
AuthorCowman, AF; Baldi, DL; Duraisingh, M; Healer, J; Mills, KE; O'Connell, RA; Thompson, J; Triglia, T; Wickham, ME; Crabb, BS
Source TitlePHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
PublisherROYAL SOC LONDON
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsCowman, A. F., Baldi, D. L., Duraisingh, M., Healer, J., Mills, K. E., O'Connell, R. A., Thompson, J., Triglia, T., Wickham, M. E. & Crabb, B. S. (2002). Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 357 (1417), pp.25-33. https://doi.org/10.1098/rstb.2001.1010.
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1692917
C1 - Journal Articles Refereed
Malaria is a major human health problem and is responsible for over 2 million deaths per year. It is caused by a number of species of the genus Plasmodium, and Plasmodium falciparum is the causative agent of the most lethal form. Consequently, the development of a vaccine against this parasite is a priority. There are a number of stages of the parasite life cycle that are being targeted for the development of vaccines. Important candidate antigens include proteins on the surface of the asexual merozoite stage, the form that invades the host erythrocyte. The development of methods to manipulate the genome of Plasmodium species has enabled the construction of gain-of-function and loss-of-function mutants and provided new strategies to analyse the role of parasite proteins. This has provided new information on the role of merozoite antigens in erythrocyte invasion and also allows new approaches to address their potential as vaccine candidates.
KeywordsMedical Microbiology not elsewhere classified; Infectious Diseases; Infectious Diseases
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