Activation of thymic regeneration in mice and humans following androgen blockade
AuthorSutherland, JS; Goldberg, GL; Hammett, MV; Uldrich, AP; Berzins, SP; Heng, TS; Blazar, BR; Millar, JL; Malin, MA; Chidgey, AP; ...
Source TitleJOURNAL OF IMMUNOLOGY
PublisherAMER ASSOC IMMUNOLOGISTS
University of Melbourne Author/sBerzins, Stuart
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsSutherland, J. S., Goldberg, G. L., Hammett, M. V., Uldrich, A. P., Berzins, S. P., Heng, T. S., Blazar, B. R., Millar, J. L., Malin, M. A., Chidgey, A. P. & Boyd, R. L. (2005). Activation of thymic regeneration in mice and humans following androgen blockade. JOURNAL OF IMMUNOLOGY, 175 (4), pp.2741-2753. https://doi.org/10.4049/jimmunol.175.4.2741.
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C1 - Journal Articles Refereed
The thymus undergoes age-related atrophy, coincident with increased circulating sex steroids from puberty. The impact of thymic atrophy is most profound in clinical conditions that cause a severe loss in peripheral T cells with the ability to regenerate adequate numbers of naive CD4+ T cells indirectly correlating with patient age. The present study demonstrates that androgen ablation results in the complete regeneration of the aged male mouse thymus, restoration of peripheral T cell phenotype and function and enhanced thymus regeneration following bone marrow transplantation. Importantly, this technique is also applicable to humans, with analysis of elderly males undergoing sex steroid ablation therapy for prostatic carcinoma, demonstrating an increase in circulating T cell numbers, particularly naive (TREC+) T cells. Collectively these studies represent a fundamentally new approach to treating immunodeficiency states in humans.
KeywordsCellular Immunology; Immune System and Allergy
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