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dc.contributor.authorSutherland, JS
dc.contributor.authorGoldberg, GL
dc.contributor.authorHammett, MV
dc.contributor.authorUldrich, AP
dc.contributor.authorBerzins, SP
dc.contributor.authorHeng, TS
dc.contributor.authorBlazar, BR
dc.contributor.authorMillar, JL
dc.contributor.authorMalin, MA
dc.contributor.authorChidgey, AP
dc.contributor.authorBoyd, RL
dc.date.available2014-05-21T19:20:45Z
dc.date.issued2005-08-15
dc.identifierpii: 175/4/2741
dc.identifier.citationSutherland, J. S., Goldberg, G. L., Hammett, M. V., Uldrich, A. P., Berzins, S. P., Heng, T. S., Blazar, B. R., Millar, J. L., Malin, M. A., Chidgey, A. P. & Boyd, R. L. (2005). Activation of thymic regeneration in mice and humans following androgen blockade. JOURNAL OF IMMUNOLOGY, 175 (4), pp.2741-2753. https://doi.org/10.4049/jimmunol.175.4.2741.
dc.identifier.issn0022-1767
dc.identifier.urihttp://hdl.handle.net/11343/26141
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe thymus undergoes age-related atrophy, coincident with increased circulating sex steroids from puberty. The impact of thymic atrophy is most profound in clinical conditions that cause a severe loss in peripheral T cells with the ability to regenerate adequate numbers of naive CD4+ T cells indirectly correlating with patient age. The present study demonstrates that androgen ablation results in the complete regeneration of the aged male mouse thymus, restoration of peripheral T cell phenotype and function and enhanced thymus regeneration following bone marrow transplantation. Importantly, this technique is also applicable to humans, with analysis of elderly males undergoing sex steroid ablation therapy for prostatic carcinoma, demonstrating an increase in circulating T cell numbers, particularly naive (TREC+) T cells. Collectively these studies represent a fundamentally new approach to treating immunodeficiency states in humans.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherAMER ASSOC IMMUNOLOGISTS
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleActivation of thymic regeneration in mice and humans following androgen blockade
dc.typeJournal Article
dc.identifier.doi10.4049/jimmunol.175.4.2741
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJOURNAL OF IMMUNOLOGY
melbourne.source.volume175
melbourne.source.issue4
melbourne.source.pages2741-2753
dc.research.coderfcd320202
dc.research.codeseo1998730102
melbourne.publicationid41746
melbourne.elementsid271807
melbourne.contributor.authorBerzins, Stuart
dc.identifier.eissn1550-6606
melbourne.accessrightsThis item is currently not available from this repository


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