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    The influence of CD1d in postselection NKT cell maturation and homeostasis

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    Author
    McNab, FW; Berzins, SP; Pellicci, DG; Kyparissoudis, K; Field, K; Smyth, MJ; Godfrey, DI
    Date
    2005-09-15
    Source Title
    JOURNAL OF IMMUNOLOGY
    Publisher
    AMER ASSOC IMMUNOLOGISTS
    University of Melbourne Author/s
    Berzins, Stuart; Pellicci, Daniel; FIELD, KENNETH; SMYTH, MARK; Godfrey, Dale; KYPARISSOUDIS, KONSTANTINOS; MCNAB, FINLAY
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    McNab, F. W., Berzins, S. P., Pellicci, D. G., Kyparissoudis, K., Field, K., Smyth, M. J. & Godfrey, D. I. (2005). The influence of CD1d in postselection NKT cell maturation and homeostasis. JOURNAL OF IMMUNOLOGY, 175 (6), pp.3762-3768. https://doi.org/10.4049/jimmunol.175.6.3762.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26149
    DOI
    10.4049/jimmunol.175.6.3762
    Description

    C1 - Journal Articles Refereed

    Abstract
    After being positively selected on CD1d-expressing thymocytes, NKT cells undergo a series of developmental changes that can take place inside or outside the thymus. We asked whether CD1d continues to play a role in late-stage NKT cell development and, in particular, during the functionally significant acquisition of NK1.1 that is indicative of NKT cell maturity. We report that CD1d is indeed crucial for this step, because immature NK1.1(-) NKT cells fail to fully mature when transferred to a CD1d-deficient environment. Surprisingly, however, the lack of CD1d did not greatly affect the long-term survival of NKT cells, and they continued to express CD69 and slowly proliferate. This directly contradicts the currently held view that these phenomena are caused by autoreactivity directed against CD1d/TCR-restricted self-Ags. Our findings demonstrate an ongoing role for TCR-mediated signaling throughout NKT cell development, but the characteristic semiactivated basal state of NKT cells is controlled by CD1d-independent factors or is intrinsic to the cells themselves.
    Keywords
    Cellular Immunology; Immune System and Allergy

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