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    Localization of Idd11 is not associated with thymus and NKT cell abnormalities in NOD mice

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    Author
    Brodnicki, TC; Fletcher, AL; Pellicci, DG; Berzins, SP; McClive, P; Quirk, F; Webster, KE; Scott, HS; Boyd, RL; Godfrey, DI; ...
    Date
    2005-12-01
    Source Title
    DIABETES
    Publisher
    AMER DIABETES ASSOC
    University of Melbourne Author/s
    Pellicci, Daniel; Berzins, Stuart; Godfrey, Dale; Mcclive, Peter
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Brodnicki, T. C., Fletcher, A. L., Pellicci, D. G., Berzins, S. P., McClive, P., Quirk, F., Webster, K. E., Scott, H. S., Boyd, R. L., Godfrey, D. I. & Morahan, G. (2005). Localization of Idd11 is not associated with thymus and NKT cell abnormalities in NOD mice. DIABETES, 54 (12), pp.3453-3457. https://doi.org/10.2337/diabetes.54.12.3453.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26150
    DOI
    10.2337/diabetes.54.12.3453
    Description

    C1 - Journal Articles Refereed

    Abstract
    Congenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an approximately 8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.
    Keywords
    Cellular Immunology; Immune System and Allergy

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