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dc.contributor.authorBrodnicki, TC
dc.contributor.authorFletcher, AL
dc.contributor.authorPellicci, DG
dc.contributor.authorBerzins, SP
dc.contributor.authorMcClive, P
dc.contributor.authorQuirk, F
dc.contributor.authorWebster, KE
dc.contributor.authorScott, HS
dc.contributor.authorBoyd, RL
dc.contributor.authorGodfrey, DI
dc.contributor.authorMorahan, G
dc.date.available2014-05-21T19:21:06Z
dc.date.issued2005-12-01
dc.identifierpii: 54/12/3453
dc.identifier.citationBrodnicki, T. C., Fletcher, A. L., Pellicci, D. G., Berzins, S. P., McClive, P., Quirk, F., Webster, K. E., Scott, H. S., Boyd, R. L., Godfrey, D. I. & Morahan, G. (2005). Localization of Idd11 is not associated with thymus and NKT cell abnormalities in NOD mice. DIABETES, 54 (12), pp.3453-3457. https://doi.org/10.2337/diabetes.54.12.3453.
dc.identifier.issn0012-1797
dc.identifier.urihttp://hdl.handle.net/11343/26150
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractCongenic mouse strains provide a unique resource for genetic dissection and biological characterization of chromosomal regions associated with diabetes progression in the nonobese diabetic (NOD) mouse. Idd11, a mouse diabetes susceptibility locus, was previously localized to a region on chromosome 4. Comparison of a panel of subcongenic NOD mouse strains with different intervals derived from the nondiabetic C57BL/6 (B6) strain now maps Idd11 to an approximately 8-Mb interval. B6-derived intervals protected congenic NOD mice from diabetes onset, even though lymphocytic infiltration of pancreatic islets was similar to that found in NOD mice. In addition, neither thymic structural irregularities nor NKT cell deficiencies were ameliorated in diabetes-resistant congenic NOD mice, indicating that Idd11 does not contribute to these abnormalities, which do not need to be corrected to prevent disease.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherAMER DIABETES ASSOC
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleLocalization of Idd11 is not associated with thymus and NKT cell abnormalities in NOD mice
dc.typeJournal Article
dc.identifier.doi10.2337/diabetes.54.12.3453
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleDIABETES
melbourne.source.volume54
melbourne.source.issue12
melbourne.source.pages3453-3457
dc.research.coderfcd320202
dc.research.codeseo1998730102
melbourne.publicationid40659
melbourne.elementsid270935
melbourne.contributor.authorPellicci, Daniel
melbourne.contributor.authorBerzins, Stuart
melbourne.contributor.authorGodfrey, Dale
melbourne.contributor.authorMcclive, Peter
dc.identifier.eissn1939-327X
melbourne.conference.locationUnited States
melbourne.accessrightsThis item is currently not available from this repository


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