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dc.contributor.authorNgo, T
dc.contributor.authorDuraisingh, M
dc.contributor.authorReed, M
dc.contributor.authorHipgrave, D
dc.contributor.authorBiggs, B
dc.contributor.authorCowman, AF
dc.date.available2014-05-21T19:21:35Z
dc.date.issued2003-03-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000181677800021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationNgo, T., Duraisingh, M., Reed, M., Hipgrave, D., Biggs, B. & Cowman, A. F. (2003). Analysis of pfcrt, pfmdr1, dhfr, and DHPS mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 68 (3), pp.350-356. https://doi.org/10.4269/ajtmh.2003.68.350.
dc.identifier.issn0002-9637
dc.identifier.urihttp://hdl.handle.net/11343/26163
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractWe have analyzed artemisinin sensitivity in Plasmodium falciparum isolates obtained from patients in South Vietnam and show that artemisinin sensitivity does not differ before and after drug treatment. There was an increase in the level of mefloquine resistance in the isolates after drug treatment that was concomitant with a decrease in chloroquine resistance, suggesting that treatment with artemisinin has selected for increased mefloquine resistance. Mutations in the pfmdr1 gene, previously shown to be associated with sensitivity to mefloquine, were selected against. All isolates resistant to chloroquine encoded Thr-76 in the pfcrt gene consistent with an essential role in the mechanism of chloroquine resistance. Mutations in pfmdr1 also were linked to chloroquine resistance. High levels of mutation in dhfr and dhps genes, which have previously been associated with Fansidar resistance, also were found, suggesting that this drug would not be useful for malaria control in this part of Vietnam.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherAMER SOC TROP MED & HYGIENE
dc.subjectClinical Pharmacology and Therapeutics; Infectious Diseases; Infectious Diseases
dc.titleAnalysis of pfcrt, pfmdr1, dhfr, and DHPS mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin
dc.typeJournal Article
dc.identifier.doi10.4269/ajtmh.2003.68.350
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne And Western Hospitals
melbourne.source.titleAMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
melbourne.source.volume68
melbourne.source.issue3
melbourne.source.pages350-356
dc.research.coderfcd320503
dc.research.coderfcd321010
dc.research.codeseo1998730101
melbourne.publicationid20160
melbourne.elementsid258374
melbourne.contributor.authorBiggs, Beverley-Ann
melbourne.contributor.authorCowman, Alan
melbourne.contributor.authorHIPGRAVE, DAVID BARRY
dc.identifier.eissn1476-1645
melbourne.accessrightsThis item is currently not available from this repository


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