Hepatitis B infection in rural Vietnam and the implications for a National Program of Infant Immunization
Author
Hipgrave, DB; Van, NT; Huong, VM; Long, HT; Dat, DT; Trung, TN; Jolley, D; Maynard, JE; Biggs, BADate
2003-09-01Source Title
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENEPublisher
AMER SOC TROP MED & HYGIENEAffiliation
Medicine - Royal Melbourne And Western HospitalsMetadata
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Journal ArticleCitations
Hipgrave, D. B., Van, N. T., Huong, V. M., Long, H. T., Dat, D. T., Trung, T. N., Jolley, D., Maynard, J. E. & Biggs, B. A. (2003). Hepatitis B infection in rural Vietnam and the implications for a National Program of Infant Immunization. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 69 (3), pp.288-294. https://doi.org/10.4269/ajtmh.2003.69.288.Access Status
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C1 - Journal Articles Refereed
Abstract
To ascertain hepatitis B virus (HBV) infection rates for Vietnam, we surveyed HBV markers in two districts of Thanh Hoa province. We randomly selected 536 infants (9- < or = 18 months old), 228 children (4 to < or = 6 years old), 219 adolescents (14 to < or = 16 years old), and 596 adults (25 to < or = 40 years old). On questioning, none of those surveyed had received vaccine against HBV. Hepatitis B virus surface antigen (HBsAg) and total HBV core antibody (anti-HBc) were measured in all specimens, and HBV e antigen (HBeAg) in those positive for HBsAg, and HBV surface antibody (anti-HBs) were measured in all others. Current infection (HBsAg+) rates were infants = 12.5%, children = 18.4%, adolescents = 20.5%, and adults = 18.8%. Current or previous infection (HBsAg+, anti-HBc+, or anti-HBs+) increased with age (infants = 19.6%, children = 36.4%, adolescents = 55.3%, adults = 79.2%). Rates of HBeAg among those HBsAg+ were infants = 85.1%, children = 88.1%, adolescents = 71.1%, and adults = 30.4%. The epidemiology of HBV in Vietnam resembles that of many southeast Asian nations before introduction of vaccine. Immunization of newborns will have enormous impact on HBV-related morbidity and mortality there.
Keywords
Infectious Diseases; Infectious DiseasesExport Reference in RIS Format
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