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    Improving birth dose coverage of hepatitis B vaccine

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    44
    Author
    Hipgrave, DB; Maynard, JE; Biggs, BA
    Date
    2006-01-01
    Source Title
    BULLETIN OF THE WORLD HEALTH ORGANIZATION
    Publisher
    WORLD HEALTH ORGANIZATION
    University of Melbourne Author/s
    Hipgrave, David; Biggs, Beverley-Ann
    Affiliation
    Medicine - Royal Melbourne And Western Hospitals
    Nossal Institute for Global Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Hipgrave, D. B., Maynard, J. E. & Biggs, B. A. (2006). Improving birth dose coverage of hepatitis B vaccine. BULLETIN OF THE WORLD HEALTH ORGANIZATION, 84 (1), pp.65-71. https://doi.org/10.2471/blt.04.017426.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/26166
    DOI
    10.2471/blt.04.017426
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626514
    Description

    C5 - Other Refereed Contribution to Refereed Journals

    Abstract
    Administration of a birth dose of hepatitis B vaccine (HepB vaccine) to neonates is recommended to prevent mother-to-infant transmission and chronic infection with the hepatitis B virus (HBV). Although manufacturers recommend HepB vaccine distribution and storage at 2-8 degrees C, recognition of the heat stability of hepatitis B surface antigen stimulated research into its use after storage at, or exposure to, ambient or high temperatures. Storage of HepB vaccine at ambient temperatures would enable birth dosing for neonates delivered at home in remote areas or at health posts lacking refrigeration. This article reviews the current evidence on the thermostability of HepB vaccine when stored outside the cold chain (OCC). The reports reviewed show that the vaccines studied were safe and effective whether stored cold or OCC. Field and laboratory data also verifies the retained potency of the vaccine after exposure to heat. The attachment of a highly stable variety of a vaccine vial monitor (measuring cumulative exposure to heat) on many HepB vaccines strongly supports policies allowing their storage OCC, when this will benefit birth dose coverage. We recommend that this strategy be introduced to improve birth dose coverage, especially in rural and remote areas. Concurrent monitoring and evaluation should be undertaken to affirm the safe implementation of this strategy, and assess its cost, feasibility and effect on reducing HBV infection rates. Meanwhile, release of manufacturer data verifying the potency of currently available HepB vaccines after exposure to heat will increase confidence in the use of vaccine vial monitors as a managerial tool during storage of HepB vaccine OCC.
    Keywords
    Medical Bacteriology ; Infectious Diseases; Infectious Diseases; Child Health; Health Related to Specific Ethnic Groups; Preventive Medicine

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