Prospective population-based incidence of Haemophilus influenzae type b meningitis in Thailand
AuthorRerks-Ngarm, S; Treleaven, SC; Chunsuttiwat, S; Muangchana, C; Jolley, D; Brooks, A; Dejsirilert, S; Warintrawat, S; Guiver, M; Kunasol, P; ...
PublisherELSEVIER SCI LTD
AffiliationMedicine - Royal Melbourne And Western Hospitals
Document TypeJournal Article
CitationsRerks-Ngarm, S., Treleaven, S. C., Chunsuttiwat, S., Muangchana, C., Jolley, D., Brooks, A., Dejsirilert, S., Warintrawat, S., Guiver, M., Kunasol, P., Maynard, J. E., Biggs, B. A. & Steinhoff, M. (2004). Prospective population-based incidence of Haemophilus influenzae type b meningitis in Thailand. VACCINE, 22 (8), pp.975-983. https://doi.org/10.1016/j.vaccine.2003.09.013.
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C1 - Journal Articles Refereed
There are limited prospective data for Haemophilus influenzae type b (Hib) disease in Asia, where some countries are considering vaccine introduction. A prospective population-based study was conducted to measure the incidence of Hib meningitis in children in two northern provinces of Thailand. Children <5 years with symptoms consistent with bacterial meningitis were enrolled in the study if inclusion criteria were met. The study enrolled 598 children with clinical meningitis, 76% of whom received lumbar puncture. The rate of probable bacterial meningitis was 26.6/100,000 children <5 years per year. There were four cases of laboratory confirmed Hib meningitis (rate 3.8/100,000 children <5 years per year). These findings suggest a relatively low incidence of Hib meningitis. However, additional data from studies of pneumonia are needed to define the Hib disease burden in Thailand.
KeywordsInfectious Diseases; Infectious Diseases
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