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    Broad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype

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    Author
    Duffy, MF; Byrne, TJ; Elliott, SR; Wilson, DW; Rogerson, SJ; Beeson, JG; Noviyanti, R; Brown, GV
    Date
    2005-05-01
    Source Title
    MOLECULAR MICROBIOLOGY
    Publisher
    WILEY-BLACKWELL
    University of Melbourne Author/s
    Duffy, Michael; Byrne, Timothy; WILSON, DANNY; Rogerson, Stephen; Brown, Graham; ELLIOTT, SALENNA; Beeson, James
    Affiliation
    Medicine - Royal Melbourne And Western Hospitals
    Metadata
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    Document Type
    Journal Article
    Citations
    Duffy, M. F., Byrne, T. J., Elliott, S. R., Wilson, D. W., Rogerson, S. J., Beeson, J. G., Noviyanti, R. & Brown, G. V. (2005). Broad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype. MOLECULAR MICROBIOLOGY, 56 (3), pp.774-788. https://doi.org/10.1111/j.1365-2958.2005.04577.x.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26210
    DOI
    10.1111/j.1365-2958.2005.04577.x
    Description

    C1 - Journal Articles Refereed

    Abstract
    Transcription of the majority of the members of the Plasmodium falciparum var multigene family were analysed in two isolates by a quantitative approach. Both of these isolates had been repeatedly selected for adhesion to chondroitin sulphate A (CSA) and one had also been selected for adhesion to hyaluronic acid (HA). These adhesion phenotypes are expressed by many parasites isolated from placentae and are associated with malaria disease in pregnancy. Increased transcription of the var gene var2csa, or its homologue IT4 var4, was associated with the CSA and HA adhesion phenotypes in all parasites suggesting that it was the dominant, if not the only, var gene that encoded adhesion to CSA in these allogeneic isolates. Some var genes were consistently transcribed at higher levels than others regardless of expressed adhesion phenotypes suggesting a transcriptional hierarchy. Unspliced or partial transcripts were detected for most var genes tested. These atypical var gene transcripts may have implications for the regulation of var gene transcription.
    Keywords
    Infectious Diseases; Infectious Diseases

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