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dc.contributor.authorDuffy, MF
dc.contributor.authorByrne, TJ
dc.contributor.authorElliott, SR
dc.contributor.authorWilson, DW
dc.contributor.authorRogerson, SJ
dc.contributor.authorBeeson, JG
dc.contributor.authorNoviyanti, R
dc.contributor.authorBrown, GV
dc.identifierpii: MMI4577
dc.identifier.citationDuffy, M. F., Byrne, T. J., Elliott, S. R., Wilson, D. W., Rogerson, S. J., Beeson, J. G., Noviyanti, R. & Brown, G. V. (2005). Broad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype. MOLECULAR MICROBIOLOGY, 56 (3), pp.774-788.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractTranscription of the majority of the members of the Plasmodium falciparum var multigene family were analysed in two isolates by a quantitative approach. Both of these isolates had been repeatedly selected for adhesion to chondroitin sulphate A (CSA) and one had also been selected for adhesion to hyaluronic acid (HA). These adhesion phenotypes are expressed by many parasites isolated from placentae and are associated with malaria disease in pregnancy. Increased transcription of the var gene var2csa, or its homologue IT4 var4, was associated with the CSA and HA adhesion phenotypes in all parasites suggesting that it was the dominant, if not the only, var gene that encoded adhesion to CSA in these allogeneic isolates. Some var genes were consistently transcribed at higher levels than others regardless of expressed adhesion phenotypes suggesting a transcriptional hierarchy. Unspliced or partial transcripts were detected for most var genes tested. These atypical var gene transcripts may have implications for the regulation of var gene transcription.
dc.subjectInfectious Diseases; Infectious Diseases
dc.titleBroad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - Royal Melbourne And Western Hospitals
melbourne.source.titleMOLECULAR MICROBIOLOGY
melbourne.contributor.authorDuffy, Michael
melbourne.contributor.authorByrne, Timothy
melbourne.contributor.authorWILSON, DANNY
melbourne.contributor.authorRogerson, Stephen
melbourne.contributor.authorBrown, Graham
melbourne.contributor.authorELLIOTT, SALENNA
melbourne.contributor.authorBeeson, James
melbourne.accessrightsThis item is currently not available from this repository

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