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    Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus

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    Author
    Deliyannis, G; Jackson, DC; Ede, NJ; Zeng, WG; Hourdakis, I; Sakabetis, E; Brown, LE
    Date
    2002-05-01
    Source Title
    JOURNAL OF VIROLOGY
    Publisher
    AMER SOC MICROBIOLOGY
    University of Melbourne Author/s
    Deliyannis, Georgia; Jackson, David; Zeng, Weiguang; Brown, Lorena; HOURDAKIS, IRENE; SAKABETIS, EVALINE
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Deliyannis, G., Jackson, D. C., Ede, N. J., Zeng, W. G., Hourdakis, I., Sakabetis, E. & Brown, L. E. (2002). Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus. JOURNAL OF VIROLOGY, 76 (9), pp.4212-4221. https://doi.org/10.1128/JVI.76.9.4212-4221.2002.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/26223
    DOI
    10.1128/JVI.76.9.4212-4221.2002
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155065
    Description

    C1 - Journal Articles Refereed

    Abstract
    Induction of cytotoxic T-cell-mediated virus-clearing responses by influenza virus T cell determinant-containing peptide immunogens was examined. The most potent synthetic immunogens for eliciting pulmonary viral-clearing responses contained peptides representing determinants for CD4 and CD8 T cells (TH and CTL peptides, respectively) together with two or four palmitic acid (Pal) groups. Inoculated in adjuvant, these Pal2- or Pal4-CTL-TH lipopeptides and the nonlipidated CTL peptide induced equivalent levels of cytolytic activity in the primary effector phase of the response. The ability to recall lytic responses, however, diminished much more rapidly in CTL peptide-primed than in lipopeptide-primed mice. By 15 months postpriming, the recalled lytic activity in lipopeptide-inoculated mice remained potent, but the response induced by the CTL peptide was weak. Enumeration of specific gamma interferon-secreting CD8 T cells revealed that a greater number of these T cells had entered or remained in the memory pool in lipopeptide-primed mice, arguing for a quantitative rather than qualitative enhancement of the response on recall. Addition of either the lipid or the TH peptide to the CTL peptide was not sufficient to provide these long-lived antiviral responses, but inclusion of both components augmented the response. CD4 T cells elicited by the lipopeptides did not influence the rate of viral clearance upon challenge and most likely had a role in induction or maintenance of the memory response. It therefore appears that the lipopeptide immunogens, although not significantly superior at inducing primary effector CD8 T cells, elicit a much more effective memory population, the recall of which may account for their superiority in inducing pulmonary protection after viral challenge.
    Keywords
    Virology ; Infectious Diseases

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