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dc.contributor.authorDeliyannis, G
dc.contributor.authorJackson, DC
dc.contributor.authorEde, NJ
dc.contributor.authorZeng, WG
dc.contributor.authorHourdakis, I
dc.contributor.authorSakabetis, E
dc.contributor.authorBrown, LE
dc.date.available2014-05-21T19:23:54Z
dc.date.issued2002-05-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000174966700007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationDeliyannis, G., Jackson, D. C., Ede, N. J., Zeng, W. G., Hourdakis, I., Sakabetis, E. & Brown, L. E. (2002). Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus. JOURNAL OF VIROLOGY, 76 (9), pp.4212-4221. https://doi.org/10.1128/JVI.76.9.4212-4221.2002.
dc.identifier.issn0022-538X
dc.identifier.urihttp://hdl.handle.net/11343/26223
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractInduction of cytotoxic T-cell-mediated virus-clearing responses by influenza virus T cell determinant-containing peptide immunogens was examined. The most potent synthetic immunogens for eliciting pulmonary viral-clearing responses contained peptides representing determinants for CD4 and CD8 T cells (TH and CTL peptides, respectively) together with two or four palmitic acid (Pal) groups. Inoculated in adjuvant, these Pal2- or Pal4-CTL-TH lipopeptides and the nonlipidated CTL peptide induced equivalent levels of cytolytic activity in the primary effector phase of the response. The ability to recall lytic responses, however, diminished much more rapidly in CTL peptide-primed than in lipopeptide-primed mice. By 15 months postpriming, the recalled lytic activity in lipopeptide-inoculated mice remained potent, but the response induced by the CTL peptide was weak. Enumeration of specific gamma interferon-secreting CD8 T cells revealed that a greater number of these T cells had entered or remained in the memory pool in lipopeptide-primed mice, arguing for a quantitative rather than qualitative enhancement of the response on recall. Addition of either the lipid or the TH peptide to the CTL peptide was not sufficient to provide these long-lived antiviral responses, but inclusion of both components augmented the response. CD4 T cells elicited by the lipopeptides did not influence the rate of viral clearance upon challenge and most likely had a role in induction or maintenance of the memory response. It therefore appears that the lipopeptide immunogens, although not significantly superior at inducing primary effector CD8 T cells, elicit a much more effective memory population, the recall of which may account for their superiority in inducing pulmonary protection after viral challenge.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherAMER SOC MICROBIOLOGY
dc.subjectVirology ; Infectious Diseases
dc.titleInduction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus
dc.typeJournal Article
dc.identifier.doi10.1128/JVI.76.9.4212-4221.2002
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJOURNAL OF VIROLOGY
melbourne.source.volume76
melbourne.source.issue9
melbourne.source.pages4212-4221
dc.research.coderfcd270303
dc.research.codeseo1998730101
melbourne.publicationid9052
melbourne.elementsid251478
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC155065
melbourne.contributor.authorDeliyannis, Georgia
melbourne.contributor.authorJackson, David
melbourne.contributor.authorZeng, Weiguang
melbourne.contributor.authorBrown, Lorena
melbourne.contributor.authorHOURDAKIS, IRENE
melbourne.contributor.authorSAKABETIS, EVALINE
dc.identifier.eissn1098-5514
melbourne.accessrightsAccess this item via the Open Access location


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