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dc.contributor.authorCamacho, SA
dc.contributor.authorHeath, WR
dc.contributor.authorCarbone, FR
dc.contributor.authorSarvetnick, N
dc.contributor.authorLeBon, A
dc.contributor.authorKarlsson, L
dc.contributor.authorPeterson, PA
dc.contributor.authorWebb, SR
dc.identifierpii: 88720
dc.identifier.citationCamacho, S. A., Heath, W. R., Carbone, F. R., Sarvetnick, N., LeBon, A., Karlsson, L., Peterson, P. A. & Webb, S. R. (2001). A key role for ICAM-I in generating effector cells mediating inflammatory responses. NATURE IMMUNOLOGY, 2 (6), pp.523-529.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractWe investigated how the accessory molecule interactions encountered during T cell priming influence T cell-mediated destruction of insulin-producing beta cells and lead to type 1 diabetes. T cell receptor (TCR)-transgenic CD4+ T cells were primed under controlled conditions in vitro before being adoptively transferred into transgenic recipients expressing membrane ovalbumin under the control of the rat insulin promoter (RIP-mOVA). During priming, antigen-presenting cell expression of B7-1 without intracellular adhesion molecule 1 (ICAM-1) led to the generation of effector cells that migrated to the pancreata of RIP-mOVA recipients but did not cause diabetes. In contrast, when T cells were primed with APCs expressing both B7-1 and ICAM-1, pronounced destruction of beta cells and a rapid onset of diabetes were observed. Pathogenicity was associated with T cell production of the macrophage-attracting chemokines CCL3 and CCL4. Thus, interactions of lymphocyte function-associated antigen 1 with ICAM-1 during priming induce both qualitative and quantitative alterations in T effector function and induce potentially autodestructive responses.
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleA key role for ICAM-I in generating effector cells mediating inflammatory responses
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleNature Immunology
melbourne.contributor.authorCarbone, Francis
melbourne.contributor.authorHeath, William
melbourne.accessrightsThis item is currently not available from this repository

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