Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity
AuthorSmith, CM; Wilson, NS; Waithman, J; Villadangos, JA; Carbone, FR; Heath, WR; Belz, GT
Source TitleNature Immunology
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sCarbone, Francis; Belz, Gabrielle; Villadangos, Jose; Heath, William; WAITHMAN, JASON CHRISTOPHER
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsSmith, C. M., Wilson, N. S., Waithman, J., Villadangos, J. A., Carbone, F. R., Heath, W. R. & Belz, G. T. (2004). Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity. NATURE IMMUNOLOGY, 5 (11), pp.1143-1148. https://doi.org/10.1038/ni1129.
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C1 - Journal Articles Refereed
Several studies have indicated that CD8(+) T cells require CD4(+) T cell help for memory formation. Evidence suggests that such help can be antigen independent, challenging whether the 'licensing' of dendritic cells (DCs) by CD4(+) T cells is ever required for cytotoxic T lymphocyte (CTL) responses. We show here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4(+) T cells mediate help in a cognate, antigen-specific way. We provide direct in vivo evidence for DC licensing by helper T cells and show that licensing is rapid and essential for the formation of effector and memory CTLs. In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing.
KeywordsCellular Immunology; Immune System and Allergy
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