University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    312
    284
    Author
    Smith, CM; Wilson, NS; Waithman, J; Villadangos, JA; Carbone, FR; Heath, WR; Belz, GT
    Date
    2004-11-01
    Source Title
    NATURE IMMUNOLOGY
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Carbone, Francis; Belz, Gabrielle; Villadangos, Jose; Heath, William; WAITHMAN, JASON CHRISTOPHER
    Affiliation
    Microbiology And Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Smith, C. M., Wilson, N. S., Waithman, J., Villadangos, J. A., Carbone, F. R., Heath, W. R. & Belz, G. T. (2004). Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity. NATURE IMMUNOLOGY, 5 (11), pp.1143-1148. https://doi.org/10.1038/ni1129.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26230
    DOI
    10.1038/ni1129
    Description

    C1 - Journal Articles Refereed

    Abstract
    Several studies have indicated that CD8(+) T cells require CD4(+) T cell help for memory formation. Evidence suggests that such help can be antigen independent, challenging whether the 'licensing' of dendritic cells (DCs) by CD4(+) T cells is ever required for cytotoxic T lymphocyte (CTL) responses. We show here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4(+) T cells mediate help in a cognate, antigen-specific way. We provide direct in vivo evidence for DC licensing by helper T cells and show that licensing is rapid and essential for the formation of effector and memory CTLs. In situations in which DCs are poorly licensed by pathogen-derived signals, our findings suggest that CTL immunity may be heavily dependent on cognate DC licensing.
    Keywords
    Cellular Immunology; Immune System and Allergy

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Microbiology & Immunology - Research Publications [1555]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors