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dc.contributor.authorWilson, NS
dc.contributor.authorBehrens, GMN
dc.contributor.authorLundie, RJ
dc.contributor.authorSmith, CM
dc.contributor.authorWaithman, J
dc.contributor.authorYoung, L
dc.contributor.authorForehan, SP
dc.contributor.authorMount, A
dc.contributor.authorSteptoe, RJ
dc.contributor.authorShortman, KD
dc.contributor.authorde Koning-Ward, TF
dc.contributor.authorBelz, GT
dc.contributor.authorCarbone, FR
dc.contributor.authorCrabb, BS
dc.contributor.authorHeath, WR
dc.contributor.authorVilladangos, JA
dc.identifierpii: ni1300
dc.identifier.citationWilson, N. S., Behrens, G. M. N., Lundie, R. J., Smith, C. M., Waithman, J., Young, L., Forehan, S. P., Mount, A., Steptoe, R. J., Shortman, K. D., de Koning-Ward, T. F., Belz, G. T., Carbone, F. R., Crabb, B. S., Heath, W. R. & Villadangos, J. A. (2006). Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. NATURE IMMUNOLOGY, 7 (2), pp.165-172.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe mechanisms responsible for the immunosuppression associated with sepsis or some chronic blood infections remain poorly understood. Here we show that infection with a malaria parasite (Plasmodium berghei) or simple systemic exposure to bacterial or viral Toll-like receptor ligands inhibited cross-priming. Reduced cross-priming was a consequence of downregulation of cross-presentation by activated dendritic cells due to systemic activation that did not otherwise globally inhibit T cell proliferation. Although activated dendritic cells retained their capacity to present viral antigens via the endogenous major histocompatibility complex class I processing pathway, antiviral responses were greatly impaired in mice exposed to Toll-like receptor ligands. This is consistent with a key function for cross-presentation in antiviral immunity and helps explain the immunosuppressive effects of systemic infection. Moreover, inhibition of cross-presentation was overcome by injection of dendritic cells bearing antigen, which provides a new strategy for generating immunity during immunosuppressive blood infections.
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleSystemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleNATURE IMMUNOLOGY
melbourne.contributor.authorCarbone, Francis
melbourne.contributor.authorCrabb, Brendan
melbourne.contributor.authorShortman, Kenneth
melbourne.contributor.authorBelz, Gabrielle
melbourne.contributor.authorVilladangos, Jose
melbourne.contributor.authorHeath, William
melbourne.contributor.authorWILSON, NICHOLAS STUART
melbourne.contributor.authorWAITHMAN, JASON CHRISTOPHER
melbourne.contributor.authorDE KONING-WARD, TANIA FRANCES
melbourne.accessrightsThis item is currently not available from this repository

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