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dc.contributor.authorWilson, NS
dc.contributor.authorBehrens, GMN
dc.contributor.authorLundie, RJ
dc.contributor.authorSmith, CM
dc.contributor.authorWaithman, J
dc.contributor.authorYoung, L
dc.contributor.authorForehan, SP
dc.contributor.authorMount, A
dc.contributor.authorSteptoe, RJ
dc.contributor.authorShortman, KD
dc.contributor.authorde Koning-Ward, TF
dc.contributor.authorBelz, GT
dc.contributor.authorCarbone, FR
dc.contributor.authorCrabb, BS
dc.contributor.authorHeath, WR
dc.contributor.authorVilladangos, JA
dc.date.available2014-05-21T19:24:46Z
dc.date.available2005-12-09
dc.date.available2005-12-09
dc.date.available2005-12-09
dc.date.available2005-12-09
dc.date.available2005-12-09
dc.date.available2005-12-09
dc.date.available2005-12-09
dc.date.available2005-12-09
dc.date.available2005-12-09
dc.date.issued2006-02-01
dc.identifierpii: ni1300
dc.identifier.citationWilson, N. S., Behrens, G. M. N., Lundie, R. J., Smith, C. M., Waithman, J., Young, L., Forehan, S. P., Mount, A., Steptoe, R. J., Shortman, K. D., de Koning-Ward, T. F., Belz, G. T., Carbone, F. R., Crabb, B. S., Heath, W. R. & Villadangos, J. A. (2006). Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. NATURE IMMUNOLOGY, 7 (2), pp.165-172. https://doi.org/10.1038/ni1300.
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/11343/26245
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractThe mechanisms responsible for the immunosuppression associated with sepsis or some chronic blood infections remain poorly understood. Here we show that infection with a malaria parasite (Plasmodium berghei) or simple systemic exposure to bacterial or viral Toll-like receptor ligands inhibited cross-priming. Reduced cross-priming was a consequence of downregulation of cross-presentation by activated dendritic cells due to systemic activation that did not otherwise globally inhibit T cell proliferation. Although activated dendritic cells retained their capacity to present viral antigens via the endogenous major histocompatibility complex class I processing pathway, antiviral responses were greatly impaired in mice exposed to Toll-like receptor ligands. This is consistent with a key function for cross-presentation in antiviral immunity and helps explain the immunosuppressive effects of systemic infection. Moreover, inhibition of cross-presentation was overcome by injection of dendritic cells bearing antigen, which provides a new strategy for generating immunity during immunosuppressive blood infections.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleSystemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
dc.typeJournal Article
dc.identifier.doi10.1038/ni1300
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleNATURE IMMUNOLOGY
melbourne.source.volume7
melbourne.source.issue2
melbourne.source.pages165-172
dc.research.coderfcd320202
dc.research.codeseo1998730102
melbourne.publicationid51409
melbourne.elementsid276957
melbourne.contributor.authorCarbone, Francis
melbourne.contributor.authorCrabb, Brendan
melbourne.contributor.authorShortman, Kenneth
melbourne.contributor.authorBelz, Gabrielle
melbourne.contributor.authorVilladangos, Jose
melbourne.contributor.authorHeath, William
melbourne.contributor.authorWILSON, NICHOLAS STUART
melbourne.contributor.authorWAITHMAN, JASON CHRISTOPHER
melbourne.contributor.authorDE KONING-WARD, TANIA FRANCES
dc.identifier.eissn1529-2916
pubs.acceptance.date2005-12-09
melbourne.accessrightsThis item is currently not available from this repository


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