Growth of rotaviruses in primary pancreatic cells
AuthorCoulson, BS; Witterick, PD; Tan, Y; Hewish, MJ; Mountford, JN; Harrison, LC; Honeyman, MC
Source TitleJournal of Virology
PublisherAMER SOC MICROBIOLOGY
University of Melbourne Author/sCoulson, Barbara; WITTERICK, PAUL DAVID; TAN, YAN; HEWISH, MARILYN JANINE
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsCoulson, B. S., Witterick, P. D., Tan, Y., Hewish, M. J., Mountford, J. N., Harrison, L. C. & Honeyman, M. C. (2002). Growth of rotaviruses in primary pancreatic cells. JOURNAL OF VIROLOGY, 76 (18), pp.9537-9544. https://doi.org/10.1128/JVI.76.18.9537-9544.2002.
Access StatusAccess this item via the Open Access location
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC136474
C1 - Journal Articles Refereed
Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.
KeywordsMedical Virology ; Infectious Diseases
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