Growth of rotaviruses in primary pancreatic cells

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    Author
    Coulson, BS; Witterick, PD; Tan, Y; Hewish, MJ; Mountford, JN; Harrison, LC; Honeyman, MC
    Date
    2002-09-01
    Source Title
    JOURNAL OF VIROLOGY
    Publisher
    AMER SOC MICROBIOLOGY
    University of Melbourne Author/s
    Coulson, Barbara; WITTERICK, PAUL DAVID; TAN, YAN; HEWISH, MARILYN JANINE
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Coulson, B. S., Witterick, P. D., Tan, Y., Hewish, M. J., Mountford, J. N., Harrison, L. C. & Honeyman, M. C. (2002). Growth of rotaviruses in primary pancreatic cells. JOURNAL OF VIROLOGY, 76 (18), pp.9537-9544. https://doi.org/10.1128/JVI.76.18.9537-9544.2002.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/26269
    DOI
    10.1128/JVI.76.18.9537-9544.2002
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136474
    Description

    C1 - Journal Articles Refereed
    Abstract
    Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.
    Keywords
    Medical Virology ; Infectious Diseases

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