Growth of rotaviruses in primary pancreatic cells
Author
Coulson, BS; Witterick, PD; Tan, Y; Hewish, MJ; Mountford, JN; Harrison, LC; Honeyman, MCDate
2002-09-01Source Title
JOURNAL OF VIROLOGYPublisher
AMER SOC MICROBIOLOGYUniversity of Melbourne Author/s
Coulson, Barbara; WITTERICK, PAUL DAVID; TAN, YAN; HEWISH, MARILYN JANINEAffiliation
Microbiology And ImmunologyMetadata
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Journal ArticleCitations
Coulson, B. S., Witterick, P. D., Tan, Y., Hewish, M. J., Mountford, J. N., Harrison, L. C. & Honeyman, M. C. (2002). Growth of rotaviruses in primary pancreatic cells. JOURNAL OF VIROLOGY, 76 (18), pp.9537-9544. https://doi.org/10.1128/JVI.76.18.9537-9544.2002.Access Status
Access this item via the Open Access locationOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC136474Description
C1 - Journal Articles Refereed
Abstract
Rotavirus infection in children at risk of developing type 1 diabetes has been temporally associated with development of pancreatic islet autoantibodies. In this study, nonobese diabetic mice were shown to be susceptible to rhesus rotavirus infection and pancreatic islets from nonobese diabetic mice, nonobese diabetes-resistant mice, fetal pigs, and macaque monkeys supported various degrees of rotavirus growth. Human rotaviruses replicated in monkey islets only. This islet susceptibility shows that rotavirus infection of the pancreas in vivo might be possible.
Keywords
Medical Virology ; Infectious DiseasesExport Reference in RIS Format
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