University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    CD127(+)CCR5(+)CD38(+++) CD4(+) Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2(+) memory CD4(+) T cells

    Thumbnail
    Citations
    Scopus
    Web of Science
    Altmetric
    37
    32
    Author
    Zaunders, JJ; Dyer, WB; Munier, ML; Ip, S; Liu, J; Amyes, E; Rawlinson, W; De Rose, R; Kent, SJ; Sullivan, JS; ...
    Date
    2006-10-01
    Source Title
    JOURNAL OF VIROLOGY
    Publisher
    AMER SOC MICROBIOLOGY
    University of Melbourne Author/s
    De Rose, Robert; Kent, Stephen
    Affiliation
    Microbiology And Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Zaunders, J. J., Dyer, W. B., Munier, M. L., Ip, S., Liu, J., Amyes, E., Rawlinson, W., De Rose, R., Kent, S. J., Sullivan, J. S., Cooper, D. A. & Kelleher, A. D. (2006). CD127(+)CCR5(+)CD38(+++) CD4(+) Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2(+) memory CD4(+) T cells. JOURNAL OF VIROLOGY, 80 (20), pp.10151-10161. https://doi.org/10.1128/JVI.02670-05.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/26286
    DOI
    10.1128/JVI.02670-05
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617315
    Description

    C1 - Journal Articles Refereed

    Abstract
    The stages of development of human antigen-specific CD4+ T cells responding to viral infection and their differentiation into long-term memory cells are not well understood. The inoculation of healthy adults with vaccinia virus presents an opportunity to study these events intensively. Between days 11 and 14 postinoculation, there was a peak of proliferating CCR5+CD38+++ CD4+ effector cells which contained the cytotoxic granule marker T-cell intracellular antigen 1 and included gamma interferon (IFN-gamma)-producing vaccinia virus-specific CD4+ T cells. The majority of these initial vaccinia virus-specific CD4+ T cells were CD127+ and produced interleukin-2 (IL-2) but not CTLA-4 in response to restimulation in vitro. Between days 14 and 21, there was a switch from IFN-gamma and IL-2 coexpression to IL-2 production only, coinciding with a resting phenotype and an increased in vitro proliferation response. The early CCR5+CD38+++ vaccinia virus-specific CD4+ T cells were similar to our previous observations of human immunodeficiency virus (HIV)-specific CD4+ T cells in primary HIV type 1 (HIV-1) infection, but the vaccinia virus-specific cells expressed much more CD127 and IL-2 than we previously found in their HIV-specific counterparts. The current study provides important information on the differentiation of IL-2+ vaccinia virus-specific memory cells, allowing further study of antiviral effector CD4+ T cells in healthy adults and their dysfunction in HIV-1 infection.
    Keywords
    Medical Virology ; Infectious Diseases

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Microbiology & Immunology - Research Publications [1555]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors