The neuroprotective effect of progesterone after traumatic brain injury in male mice is independent of both the inflammatory response and growth factor expression
AuthorJones, NC; Constantin, D; Prior, MJW; Morris, PG; Marsden, CA; Murphy, S
Source TitleEUROPEAN JOURNAL OF NEUROSCIENCE
University of Melbourne Author/sJones, Nigel
AffiliationMedicine - Royal Melbourne And Western Hospitals
Document TypeJournal Article
CitationsJones, N. C., Constantin, D., Prior, M. J. W., Morris, P. G., Marsden, C. A. & Murphy, S. (2005). The neuroprotective effect of progesterone after traumatic brain injury in male mice is independent of both the inflammatory response and growth factor expression. EUROPEAN JOURNAL OF NEUROSCIENCE, 21 (6), pp.1547-1554. https://doi.org/10.1111/j.1460-9568.2005.03995.x.
Access StatusThis item is currently not available from this repository
C1 - Journal Articles Refereed
Previous studies suggest that progesterone may possess neuroprotective properties after traumatic insult but, with the exception of reduced formation of cerebral oedema, limited experimental evidence has been presented to support this claim. In the present study we focused on the effect of progesterone treatment on structural and functional deficits in an experimental model of traumatic brain injury. Female mice exhibited significantly (P = 0.0445) reduced lesion volumes compared with males after aseptic cryogenic cerebral injury (ACI), suggesting that female sex steroids provide protection against this injury. In male mice, progesterone treatment after injury (three intraperitoneal doses of 8 mg/kg) reduced lesion volume (P = 0.0429) and improved performance in a spatial cognitive task (Morris water maze; P = 0.0014). However, progesterone had no demonstrable effect on the formation of oedema as measured using T2-weighted magnetic resonance imaging, nor did it affect brain water content. The pro-inflammatory cytokines TNF-alpha and IL-1beta, and growth factors BDNF and G-CSF, were all strongly transcriptionally activated after ACI. However, progesterone administration did not affect expression of these genes. This study provides strong evidence that progesterone possesses neuroprotective properties in a mouse model of traumatic brain injury, but suggests that the steroid achieves this effect through mechanism(s) independent of the inflammatory response or growth factor up-regulation.
KeywordsCentral Nervous System ; Nervous System and Disorders
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References