Show simple item record

dc.contributor.authorDale, CJ
dc.contributor.authorDe Rose, R
dc.contributor.authorStratov, I
dc.contributor.authorChea, S
dc.contributor.authorMontefiori, DC
dc.contributor.authorThomson, S
dc.contributor.authorRamshaw, IA
dc.contributor.authorCoupar, BEH
dc.contributor.authorBoyle, DB
dc.contributor.authorLaw, M
dc.contributor.authorKent, SJ
dc.identifierpii: 78/24/13819
dc.identifier.citationDale, C. J., De Rose, R., Stratov, I., Chea, S., Montefiori, D. C., Thomson, S., Ramshaw, I. A., Coupar, B. E. H., Boyle, D. B., Law, M. & Kent, S. J. (2004). Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus. JOURNAL OF VIROLOGY, 78 (24), pp.13819-13828.
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractFurther advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox virus priming and boosting vaccines for immunogenicity and protective efficacy in outbred pigtail macaques. The number of vaccinations required, the effect of DNA vaccination alone, and the effect of cytokine (gamma interferon) coexpression by the fowlpox virus boost was also studied. A coordinated induction of high levels of broadly reactive CD4 and CD8 T-cell immune responses was induced by sequential DNA and fowlpox virus vaccination. The immunogenicity of regimens utilizing fowlpox virus coexpressing gamma interferon, a single DNA priming vaccination, or DNA vaccines alone was inferior. Significant control of a virulent SHIV challenge was observed despite a loss of SHIV-specific proliferating T cells. The outcome of challenge with virulent SHIV(mn229) correlated with vaccine immunogenicity except that DNA vaccination alone primed for protection almost as effectively as the DNA/fowlpox virus regimen despite negligible immunogenicity by standard assays. These studies suggest that priming of immunity with DNA and fowlpox virus vaccines could delay AIDS in humans.
dc.subjectMedical Biochemistry: Nucleic Acids; Infectious Diseases
dc.titleEfficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus
dc.typeJournal Article
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJOURNAL OF VIROLOGY
melbourne.contributor.authorDe Rose, Robert
melbourne.contributor.authorSTRATOV, IVAN
melbourne.contributor.authorKent, Stephen
melbourne.contributor.authorBatten, Caroline
melbourne.contributor.authorChea, Socheata
melbourne.accessrightsAccess this item via the Open Access location

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record