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    Analysis of clonotype distribution and persistence for an influenza virus-specific CD8(+) T cell response

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    Author
    Turner, SJ; Diaz, G; Cross, R; Doherty, PC
    Date
    2003-04-01
    Source Title
    IMMUNITY
    Publisher
    CELL PRESS
    University of Melbourne Author/s
    Turner, Stephen; Doherty, Peter
    Affiliation
    Microbiology And Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Turner, S. J., Diaz, G., Cross, R. & Doherty, P. C. (2003). Analysis of clonotype distribution and persistence for an influenza virus-specific CD8(+) T cell response. IMMUNITY, 18 (4), pp.549-559. https://doi.org/10.1016/S1074-7613(03)00087-6.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26303
    DOI
    10.1016/S1074-7613(03)00087-6
    Description

    C1 - Journal Articles Refereed

    Abstract
    The spectrum of TCR V beta usage is compared for primary and recall CD8(+)D(b)PA(224)(+) T cell responses in mice with influenza pneumonia. Single-cell RT-PCR established that the same clonotypes were present in the lymphoid tissue and in the virus-infected lung. Longitudinal analysis indicated that the memory TCR repertoire reflects the primary response, with no decrease in diversity prior to (or after) secondary challenge. The re-engagement of memory T cells looked to be stochastic in this localized, transient infection. Analysis of clonotypes from the blood, spleen, regional lymph nodes, bone marrow, lung, and liver over a 200 day interval showed no evidence of selective localization or loss. The long-term distribution of memory T cells seemed to be essentially random.
    Keywords
    Cellular Immunology; Immune System and Allergy

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