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    Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation

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    Author
    Marty, AJ; Thompson, JK; Duffy, MF; Voss, TS; Cowman, AF; Crabb, BS
    Date
    2006-10-01
    Source Title
    MOLECULAR MICROBIOLOGY
    Publisher
    WILEY
    University of Melbourne Author/s
    Duffy, Michael; Cowman, Alan
    Affiliation
    Medicine - Royal Melbourne And Western Hospitals
    Metadata
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    Document Type
    Journal Article
    Citations
    Marty, A. J., Thompson, J. K., Duffy, M. F., Voss, T. S., Cowman, A. F. & Crabb, B. S. (2006). Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation. MOLECULAR MICROBIOLOGY, 62 (1), pp.72-83. https://doi.org/10.1111/j.1365-2958.2006.05364.x.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26311
    DOI
    10.1111/j.1365-2958.2006.05364.x
    Description

    C1 - Journal Articles Refereed

    Abstract
    The malaria parasite Plasmodium falciparum undergoes antigenic variation through allelic exclusion and variant expression of surface proteins encoded by the var gene family. Regulation of var genes is under epigenetic control and involves reversible silencing and activation that requires the physical repositioning of a var locus into a transcriptionally permissive zone of the nuclear periphery. P. falciparum chromosome ends appear to aggregate into large perinuclear clusters which house both subtelomeric and chromosome central var genes. In this study we further define the composition of telomeric clusters using fluorescent in situ hybridization, and provide evidence that chromosome end clusters are formed by cross-linking protein. In addition, we demonstrate that a subtelomeric reporter gene and a var gene remain within clusters regardless of their transcriptional status. Our findings support a model whereby a highly localized structure dedicated to the activation of a single var gene can be housed within a gene dense chromosome end cluster that is otherwise transcriptionally silent.
    Keywords
    Medical Parasitology ; Infectious Diseases; Infectious Diseases

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