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    Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium faiciparum

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    341
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    Author
    Duraisingh, MT; Voss, TS; Marty, AJ; Duffy, MF; Good, RT; Thompson, JK; Freitas-Junior, LH; Scherf, A; Crabb, BS; Cowman, AF
    Date
    2005-04-08
    Source Title
    CELL
    Publisher
    CELL PRESS
    University of Melbourne Author/s
    Duffy, Michael; Cowman, Alan
    Affiliation
    Medicine - Royal Melbourne And Western Hospitals
    Metadata
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    Document Type
    Journal Article
    Citations
    Duraisingh, M. T., Voss, T. S., Marty, A. J., Duffy, M. F., Good, R. T., Thompson, J. K., Freitas-Junior, L. H., Scherf, A., Crabb, B. S. & Cowman, A. F. (2005). Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium faiciparum. CELL, 121 (1), pp.13-24. https://doi.org/10.1016/j.cell.2005.01.036.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26312
    DOI
    10.1016/j.cell.2005.01.036
    Description

    C1 - Journal Articles Refereed

    Abstract
    The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate that both a subtelomeric transgene and var genes are subject to reversible gene silencing. Var gene silencing involves the SIR complex as gene disruption of PfSIR2 results in activation of this gene family. We also demonstrate that perinuclear gene activation involves chromatin alterations and repositioning into a location that may be permissive for transcription. Together, this implies that locus repositioning and heterochromatic silencing play important roles in the epigenetic regulation of virulence genes in P. falciparum.
    Keywords
    Infectious Diseases; Infectious Diseases

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