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    Haloviruses HF1 and HF2: evidence for a recent and large recombination event.

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    Author
    Tang, S-L; Nuttall, S; Dyall-Smith, M
    Date
    2004-05
    Source Title
    J Bacteriol
    Publisher
    American Society for Microbiology
    University of Melbourne Author/s
    Tang, Sen-Lin; Dyall-Smith, Michael
    Affiliation
    Microbiology And Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Tang, S. -L., Nuttall, S. & Dyall-Smith, M. (2004). Haloviruses HF1 and HF2: evidence for a recent and large recombination event.. J Bacteriol, 186 (9), pp.2810-2817. https://doi.org/10.1128/jb.186.9.2810-2817.2004.
    Access Status
    Access this item via the Open Access location
    URI
    http://hdl.handle.net/11343/26317
    DOI
    10.1128/jb.186.9.2810-2817.2004
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387818
    Description

    C1 - Journal Articles Refereed

    Abstract
    Haloviruses HF1 and HF2 were isolated from the same saltern pond and are adapted to hypersaline conditions, where they infect a broad range of haloarchaeal species. The HF2 genome has previously been reported. The complete sequence of the HF1 genome has now been determined, mainly by PCR and primer walking. It was 75,898 bp in length and was 94.4% identical to the HF2 genome but about 1.8 kb shorter. A total of 117 open reading frames and five tRNA-like genes were predicted, and their database matches and characteristics were similar to those found in HF2. A comparison of the predicted restriction digest patterns based on nucleotide sequence with the observed restriction digest patterns of viral DNA showed that, unlike the case for HF2, some packaged HF1 DNA had cohesive termini. Except for a single base change, HF1 and HF2 were identical in sequence over the first 48 kb, a region that includes the early and middle genes. The remaining 28 kb of HF1 showed many differences from HF2, and the similarity of the two genomes over this late gene region was 87%. The abrupt shift in sequence similarity around 48 kb suggests a recent recombination event between either HF1 or HF2 and another HF-like halovirus that has swapped most of the right-end 28 kb. This example indicates there is a high level of recombination among viruses that live in this extreme environment.
    Keywords
    Archaebacteriology ; Biological Sciences

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