Human androgen deficiency: Insights gained from androgen receptor knockout mouse models
Loading...
Citations
Web of Science:
Altmetric:
Altmetric::
Download
Associated Records
File Licence
Editors
Date
2014-03-01
Source Title
Asian Journal of Andrology
Journal Title
Journal ISSN
Volume Title
Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
Melbourne Authors
Affiliation
Medical Education
Medicine (Austin & Northern Health)
Medicine (Austin & Northern Health)
Document Type
Journal Article
Subject Code
Citation
Rana, K., Davey, R. A. & Zajac, J. D. (2014). Human androgen deficiency: Insights gained from androgen receptor knockout mouse models. Asian Journal of Andrology, 16 (2), pp.169-177. https://doi.org/10.4103/1008-682X.122590.
Access Status
Open Access
Access URL
Open Access URL
Open Access at PMC
Linked Resource URL
NHMRC Grant Code
ARC Grant Code
Description
Abstract
The mechanism of androgen action is complex. Recently, significant advances have been made into our understanding of how androgens act via the androgen receptor (AR) through the use of genetically modified mouse models. A number of global and tissue-specific AR knockout (ARKO) models have been generated using the Cre-loxP system which allows tissue- and/or cell-specific deletion. These ARKO models have examined a number of sites of androgen action including the cardiovascular system, the immune and hemopoetic system, bone, muscle, adipose tissue, the prostate and the brain. This review focuses on the insights that have been gained into human androgen deficiency through the use of ARKO mouse models at each of these sites of action, and highlights the strengths and limitations of these Cre-loxP mouse models that should be considered to ensure accurate interpretation of the phenotype.