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    MHC class I allele frequencies in pigtail macaques of diverse origin

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    Author
    Pratt, BF; O'Connor, DH; Lafont, BAP; Mankowski, JL; Fernandez, CS; Triastuti, R; Brooks, AG; Kent, SJ; Smith, MZ
    Date
    2006-12-01
    Source Title
    IMMUNOGENETICS
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Fernandez, Caroline; Brooks, Andrew; Kent, Stephen; PRATT, BRIDGET FRANCES; Pratt, Bridget; Smith, Miranda
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Pratt, B. F., O'Connor, D. H., Lafont, B. A. P., Mankowski, J. L., Fernandez, C. S., Triastuti, R., Brooks, A. G., Kent, S. J. & Smith, M. Z. (2006). MHC class I allele frequencies in pigtail macaques of diverse origin. IMMUNOGENETICS, 58 (12), pp.995-1001. https://doi.org/10.1007/s00251-006-0164-8.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26333
    DOI
    10.1007/s00251-006-0164-8
    Description

    C1 - Journal Articles Refereed

    Abstract
    Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; however, MHC class I alleles have not yet been comprehensively characterized in pigtail macaques. The frequencies of ten previously defined alleles (four Mane-A and six Mane-B) were investigated in detail in 109 pigtail macaques using reference strand-mediated conformational analysis (RSCA). The macaques were derived from three separate breeding colonies in the USA, Indonesia and Australia, and allele frequencies were analysed within and between these groups. Mane-A*10, an allele that restricts the immunodominant SIV Gag epitope KP9, was the most common allele, present in 32.1% of the animals overall, with similar frequencies across the three cohorts. Additionally, RSCA identified a new allele (Mane-A*17) common to three Indonesian pigtail macaques responding to the same Gag CD8(+) T cell epitope. This broad characterization of common MHC class I alleles in more than 100 pigtail macaques further develops this animal model for the study of virus-specific CD8(+) T cell responses.
    Keywords
    Medical Virology ; Infectious Diseases

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