MHC class I allele frequencies in pigtail macaques of diverse origin
AuthorPratt, BF; O'Connor, DH; Lafont, BAP; Mankowski, JL; Fernandez, CS; Triastuti, R; Brooks, AG; Kent, SJ; Smith, MZ
University of Melbourne Author/sFernandez, Caroline; Brooks, Andrew; Kent, Stephen; PRATT, BRIDGET FRANCES; Pratt, Bridget; Smith, Miranda
AffiliationMicrobiology And Immunology
Document TypeJournal Article
CitationsPratt, B. F., O'Connor, D. H., Lafont, B. A. P., Mankowski, J. L., Fernandez, C. S., Triastuti, R., Brooks, A. G., Kent, S. J. & Smith, M. Z. (2006). MHC class I allele frequencies in pigtail macaques of diverse origin. IMMUNOGENETICS, 58 (12), pp.995-1001. https://doi.org/10.1007/s00251-006-0164-8.
Access StatusThis item is currently not available from this repository
C1 - Journal Articles Refereed
Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; however, MHC class I alleles have not yet been comprehensively characterized in pigtail macaques. The frequencies of ten previously defined alleles (four Mane-A and six Mane-B) were investigated in detail in 109 pigtail macaques using reference strand-mediated conformational analysis (RSCA). The macaques were derived from three separate breeding colonies in the USA, Indonesia and Australia, and allele frequencies were analysed within and between these groups. Mane-A*10, an allele that restricts the immunodominant SIV Gag epitope KP9, was the most common allele, present in 32.1% of the animals overall, with similar frequencies across the three cohorts. Additionally, RSCA identified a new allele (Mane-A*17) common to three Indonesian pigtail macaques responding to the same Gag CD8(+) T cell epitope. This broad characterization of common MHC class I alleles in more than 100 pigtail macaques further develops this animal model for the study of virus-specific CD8(+) T cell responses.
KeywordsMedical Virology ; Infectious Diseases
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References