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dc.contributor.authorPratt, BF
dc.contributor.authorO'Connor, DH
dc.contributor.authorLafont, BAP
dc.contributor.authorMankowski, JL
dc.contributor.authorFernandez, CS
dc.contributor.authorTriastuti, R
dc.contributor.authorBrooks, AG
dc.contributor.authorKent, SJ
dc.contributor.authorSmith, MZ
dc.date.available2014-05-21T19:28:17Z
dc.date.available2006-09-21
dc.date.available2006-09-21
dc.date.available2006-09-21
dc.date.available2006-09-21
dc.date.issued2006-12-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243072900006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifier.citationPratt, B. F., O'Connor, D. H., Lafont, B. A. P., Mankowski, J. L., Fernandez, C. S., Triastuti, R., Brooks, A. G., Kent, S. J. & Smith, M. Z. (2006). MHC class I allele frequencies in pigtail macaques of diverse origin. IMMUNOGENETICS, 58 (12), pp.995-1001. https://doi.org/10.1007/s00251-006-0164-8.
dc.identifier.issn0093-7711
dc.identifier.urihttp://hdl.handle.net/11343/26333
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractPigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS. Major Histocompatibility complex (MHC) class I-restricted CD8(+) T cell responses are a critical part of the adaptive immune response to HIV-1 in humans and simian immunodeficiency virus (SIV) in macaques; however, MHC class I alleles have not yet been comprehensively characterized in pigtail macaques. The frequencies of ten previously defined alleles (four Mane-A and six Mane-B) were investigated in detail in 109 pigtail macaques using reference strand-mediated conformational analysis (RSCA). The macaques were derived from three separate breeding colonies in the USA, Indonesia and Australia, and allele frequencies were analysed within and between these groups. Mane-A*10, an allele that restricts the immunodominant SIV Gag epitope KP9, was the most common allele, present in 32.1% of the animals overall, with similar frequencies across the three cohorts. Additionally, RSCA identified a new allele (Mane-A*17) common to three Indonesian pigtail macaques responding to the same Gag CD8(+) T cell epitope. This broad characterization of common MHC class I alleles in more than 100 pigtail macaques further develops this animal model for the study of virus-specific CD8(+) T cell responses.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherSPRINGER
dc.subjectMedical Virology ; Infectious Diseases
dc.titleMHC class I allele frequencies in pigtail macaques of diverse origin
dc.typeJournal Article
dc.identifier.doi10.1007/s00251-006-0164-8
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleIMMUNOGENETICS
melbourne.source.volume58
melbourne.source.issue12
melbourne.source.pages995-1001
dc.research.coderfcd320402
dc.research.codeseo1998730101
melbourne.publicationid51461
melbourne.elementsid276977
melbourne.contributor.authorFernandez, Caroline
melbourne.contributor.authorBrooks, Andrew
melbourne.contributor.authorKent, Stephen
melbourne.contributor.authorPRATT, BRIDGET FRANCES
melbourne.contributor.authorPratt, Bridget
melbourne.contributor.authorSmith, Miranda
dc.identifier.eissn1432-1211
pubs.acceptance.date2006-09-21
melbourne.accessrightsThis item is currently not available from this repository


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