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    Subtype AE HIV-1 DNA and recombinant Fowlpoxvirus vaccines encoding five shared HIV-1 genes: safety and T cell immunogenicity in macaques

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    Author
    De Rose, R; Chea, S; Dale, CJ; Reece, J; Fernandez, CS; Wilson, KM; Thomson, S; Ramshaw, IA; Coupar, BEH; Boyle, DB; ...
    Date
    2005-03-14
    Source Title
    VACCINE
    Publisher
    ELSEVIER SCI LTD
    University of Melbourne Author/s
    De Rose, Robert; Reece, Jeanette; Fernandez, Caroline; Kent, Stephen; Chea, Socheata; Batten, Caroline; SULLIVAN, MARK
    Affiliation
    Microbiology And Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    De Rose, R., Chea, S., Dale, C. J., Reece, J., Fernandez, C. S., Wilson, K. M., Thomson, S., Ramshaw, I. A., Coupar, B. E. H., Boyle, D. B., Sullivan, M. T. & Kent, S. J. (2005). Subtype AE HIV-1 DNA and recombinant Fowlpoxvirus vaccines encoding five shared HIV-1 genes: safety and T cell immunogenicity in macaques. VACCINE, 23 (16), pp.1949-1956. https://doi.org/10.1016/j.vaccine.2004.10.012.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26334
    DOI
    10.1016/j.vaccine.2004.10.012
    Description

    C1 - Journal Articles Refereed

    Abstract
    To induce broad T cell immunity to HIV-1, we evaluated the safety, immunogenicity and dose-response relationship of DNA and recombinant Fowlpoxvirus (rFPV) vaccines encoding five shared HIV subtype AE genes (Gag, Pol, Env, Tat, Rev) in pigtail macaques. The DNA (three doses of either 1 mg or 4.5 mg) and rFPV (a single boost of either 5 x 10(7) or 2 x 10(8) plaque forming units) vaccines were administered intramuscularly without adjuvants. Broadly reactive HIV-specific T cell immunity was stimulated by all doses of the vaccines administered, without significant differences between the high and low doses studied. The vaccines induced both CD4 and CD8 T cell responses to Gag, Pol, Env and Tat/Rev proteins, with CD4 T cell responses being greater in magnitude than CD8 T cell responses. The vaccine-induced T cell responses had significant cross-recognition of heterologous HIV-1 proteins from non-AE HIV-1 subtypes. In conclusion, these subtype AE HIV-1 DNA and rFPV vaccines were safe, induced broad T-cell immunity in macaques, and are suitable for progression into clinical trials.
    Keywords
    Medical Biochemistry: Nucleic Acids; Infectious Diseases

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