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dc.contributor.authorHoy, JF
dc.contributor.authorGahan, ME
dc.contributor.authorCarr, A
dc.contributor.authorSmith, D
dc.contributor.authorLewin, SR
dc.contributor.authorWesselingh, S
dc.contributor.authorCooper, DA
dc.date.available2014-05-21T19:28:23Z
dc.date.available2004-02-25
dc.date.available2004-02-25
dc.date.available2004-02-25
dc.date.available2004-02-25
dc.date.issued2004-08-15
dc.identifierpii: JID31848
dc.identifier.citationHoy, J. F., Gahan, M. E., Carr, A., Smith, D., Lewin, S. R., Wesselingh, S. & Cooper, D. A. (2004). Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir. JOURNAL OF INFECTIOUS DISEASES, 190 (4), pp.688-692. https://doi.org/10.1086/422602.
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/11343/26335
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractIt has been suggested that lipoatrophy associated with exposure to nucleoside analogues is caused by depletion of mitochondrial DNA (mtDNA). The aim of the present study was to determine whether switching treatment from a thymidine analogue to abacavir was associated with an increase in the mtDNA copy number in peripheral blood mononuclear cells (PBMCs). Of 111 patients with lipoatrophy who were randomized to have treatment switched to abacavir or to continue treatment with thymidine analogues, 94 patients had PBMCs obtained at baseline and at weeks 4, 12, and 24, for quantification of the mtDNA copy number. During the 24-week study, there was no significant change in mtDNA copy numbers in PBMCs in either treatment group, despite improvement in peripheral lipoatrophy among patients whose treatment was switched to abacavir.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherUNIV CHICAGO PRESS
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleChanges in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir
dc.typeJournal Article
dc.identifier.doi10.1086/422602
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMicrobiology And Immunology
melbourne.source.titleJOURNAL OF INFECTIOUS DISEASES
melbourne.source.volume190
melbourne.source.issue4
melbourne.source.pages688-692
dc.research.coderfcd320202
dc.research.codeseo1998730102
melbourne.publicationid30961
melbourne.elementsid265078
melbourne.contributor.authorLewin, Sharon
dc.identifier.eissn1537-6613
pubs.acceptance.date2004-02-25
melbourne.accessrightsThis item is currently not available from this repository


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