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dc.contributor.authorNikolaou, S
dc.contributor.authorHu, M
dc.contributor.authorChilton, NB
dc.contributor.authorHartman, D
dc.contributor.authorNisbet, AJ
dc.contributor.authorPresidente, PJA
dc.contributor.authorGasser, RB
dc.date.available2014-05-21T19:28:28Z
dc.date.available2005-12-25
dc.date.available2005-12-25
dc.date.available2005-12-25
dc.date.available2005-12-25
dc.date.available2005-12-25
dc.date.available2005-12-25
dc.date.available2005-12-25
dc.date.available2005-12-25
dc.date.available2005-12-25
dc.date.issued2006-05-01
dc.identifierpii: S0734-9750(06)00003-6
dc.identifier.citationNikolaou, S., Hu, M., Chilton, N. B., Hartman, D., Nisbet, A. J., Presidente, P. J. A. & Gasser, R. B. (2006). Class II myosins in nematodes - genetic relationships, fundamental and applied implications. BIOTECHNOLOGY ADVANCES, 24 (3), pp.338-350. https://doi.org/10.1016/j.biotechadv.2005.12.004.
dc.identifier.issn0734-9750
dc.identifier.urihttp://hdl.handle.net/11343/26337
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractMyosins are represented by a wide range of different classes of molecule, of which the most extensively studied are the class II myosins which drive muscle contraction and cell organization; the functional unit of class II myosins comprises two myosin heavy chains (MHCs). This minireview gives an update on class II MHCs of nematodes and describes a comparative analysis of MHC genes from nematodes and other organismal groups. Genetic analyses of sequence data for the four functional domains of MHCs (i.e., the SH3-like N-terminal, head, neck and tail domains) reveal a delineation between both the nematode and non-nematode myosins and between muscle and non-muscle myosins. The distinctiveness of the MHCs of nematodes suggests functional and tissue specialization. The elucidation of the functional roles of myosins and other molecules in specific signaling pathways in nematodes has the potential to lead to new intervention strategies for parasites via the specific disruption or interruption of key developmental processes, having biotechnological implications in the longer term.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.subjectParasitology ; Biological Sciences
dc.titleClass II myosins in nematodes - genetic relationships, fundamental and applied implications
dc.typeJournal Article
dc.identifier.doi10.1016/j.biotechadv.2005.12.004
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentVeterinary Science
melbourne.source.titleBIOTECHNOLOGY ADVANCES
melbourne.source.volume24
melbourne.source.issue3
melbourne.source.pages338-350
dc.research.coderfcd300508
dc.research.codeseo1998780105
melbourne.publicationid58463
melbourne.elementsid281506
melbourne.contributor.authorHu, Min
melbourne.contributor.authorGasser, Robin
melbourne.contributor.authorNIKOLAOU, ATHANASIA
dc.identifier.eissn1873-1899
pubs.acceptance.date2005-12-25
melbourne.accessrightsThis item is currently not available from this repository


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