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dc.contributor.authorKelly, JM
dc.contributor.authorDarcy, PK
dc.contributor.authorMarkby, JL
dc.contributor.authorGodfrey, DI
dc.contributor.authorTakedo, K
dc.contributor.authorYagita, H
dc.contributor.authorSmyth, MJ
dc.date.available2014-05-21T19:30:01Z
dc.date.issued2002-01-01
dc.identifierpii: ni746
dc.identifier.citationKelly, J. M., Darcy, P. K., Markby, J. L., Godfrey, D. I., Takedo, K., Yagita, H. & Smyth, M. J. (2002). Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection. NATURE IMMUNOLOGY, 3 (1), pp.83-90. https://doi.org/10.1038/ni746.
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/11343/26375
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractNatural killer (NK) cells may modulate the development of adaptive immune responses, but until now there has been little evidence to support this hypothesis. We investigated the primary and secondary immunity elicited by various tumor cell lines that express CD70 and interact with CD70 ligand (CD27), which is constitutively expressed on NK cells. CD70 expression enhanced primary tumor rejection in vivo as well as T cell immunity against secondary tumor challenge. Primary rejection of major histocompatibility complex (MHC) class I-deficient RMA-S.CD70 tumor cells was mediated by NK cells and perforin- and interferon-gamma-dependent mechanisms. This NK cell-mediated process also efficiently evoked the subsequent development of tumor-specific cytotoxic and T helper type 1 responses to the parental, MHC class I-sufficient, RMA tumor cells. Thus CD27-CD70 interactions provide a key link between innate NK cell responses and adaptive T cell immunity.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.subjectTumor Immunology ; Cancer and Related Disorders
dc.titleInduction of tumor-specific T cell memory by NK cell-mediated tumor rejection
dc.typeJournal Article
dc.identifier.doi10.1038/ni746
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentPathology
melbourne.source.titleNATURE IMMUNOLOGY
melbourne.source.volume3
melbourne.source.issue1
melbourne.source.pages83-90
dc.research.coderfcd320206
dc.research.codeseo1998730108
melbourne.publicationid10781
melbourne.elementsid253180
melbourne.contributor.authorDarcy, Phillip
melbourne.contributor.authorGodfrey, Dale
melbourne.contributor.authorSMYTH, MARK
dc.identifier.eissn1529-2916
melbourne.accessrightsThis item is currently not available from this repository


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