A pilot randomized, double-blind, placebo-controlled study of granisetron in the treatment of sexual dysfunction in women associated with antidepressant use
AuthorJespersen, S; Berk, M; Van Wyk, C; Dean, O; Dodd, S; Szabo, CP; Maud, C
Source TitleINTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
PublisherLIPPINCOTT WILLIAMS & WILKINS
AffiliationClinical And Biomedical Sciences
Document TypeJournal Article
CitationsJespersen, S., Berk, M., Van Wyk, C., Dean, O., Dodd, S., Szabo, C. P. & Maud, C. (2004). A pilot randomized, double-blind, placebo-controlled study of granisetron in the treatment of sexual dysfunction in women associated with antidepressant use. INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 19 (3), pp.161-164. https://doi.org/10.1097/00004850-200405000-00007.
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C1 - Journal Articles Refereed
A pilot study was conducted to evaluate the usefulness of granisetron for the treatment of antidepressant induced sexual dysfunction in women. Twelve women with antidepressant induced sexual dysfunction (AISD) were assigned granisetron (n=5) or placebo (n=7) in a 14-day randomized, double-blind, placebo-controlled study. One participant in the granisetron group did not complete the study. Participants were assessed at baseline, day 7 and day 14 using the Feiger Sexual Function and Satisfaction Questionnaire and the Arizona Sexual Experience Scale. No statistical differences were measured at baseline or at endpoint between the granisetron or placebo group. This study did not produce evidence supporting the usefulness of granisetron in AISD.
KeywordsPsychiatry ; Mental Health
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