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    Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation

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    127
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    Author
    Chong, MMW; Cornish, AL; Darwiche, R; Stanley, EG; Purton, JF; Godfrey, DI; Hilton, DJ; Starr, R; Alexander, WS; Kay, TWH
    Date
    2003-04-01
    Source Title
    IMMUNITY
    Publisher
    CELL PRESS
    University of Melbourne Author/s
    Godfrey, Dale; Kay, Thomas; Cornish, Ann; Chong, Mark; Stanley, Edouard
    Affiliation
    Medicine - St Vincent'S Hospital
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Chong, M. M. W., Cornish, A. L., Darwiche, R., Stanley, E. G., Purton, J. F., Godfrey, D. I., Hilton, D. J., Starr, R., Alexander, W. S. & Kay, T. W. H. (2003). Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation. IMMUNITY, 18 (4), pp.475-487. https://doi.org/10.1016/S1074-7613(03)00078-5.
    Access Status
    This item is currently not available from this repository
    URI
    http://hdl.handle.net/11343/26381
    DOI
    10.1016/S1074-7613(03)00078-5
    Description

    C1 - Journal Articles Refereed

    Abstract
    To determine the tissue-specific functions of SOCS-1, mice were generated in which the SOCS-1 gene could be deleted in individual tissues. A reporter gene of SOCS-1 promoter activity was also inserted. Using the reporter, high SOCS-1 expression was found at the CD4(+)CD8(+) stage in thymocyte development. To investigate the function of this expression, the SOCS-1 gene was specifically deleted throughout the thymocyte/T/NKT cell compartment. Unlike SOCS-1(-/-) mice, these mice did not develop lethal multiorgan inflammation but developed multiple lymphoid abnormalities, including enhanced differentiation of thymocytes toward CD8(+) T cells and very high percentages of peripheral CD8(+) T cells with a memory phenotype (CD44(hi)CD25(lo)CD69(lo)). These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines.
    Keywords
    Cellular Immunology; Immune System and Allergy

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