Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation
AuthorChong, MMW; Cornish, AL; Darwiche, R; Stanley, EG; Purton, JF; Godfrey, DI; Hilton, DJ; Starr, R; Alexander, WS; Kay, TWH
University of Melbourne Author/sGodfrey, Dale; Kay, Thomas; Cornish, Ann; Chong, Mark; Stanley, Edouard
AffiliationMedicine - St Vincent'S Hospital
Document TypeJournal Article
CitationsChong, M. M. W., Cornish, A. L., Darwiche, R., Stanley, E. G., Purton, J. F., Godfrey, D. I., Hilton, D. J., Starr, R., Alexander, W. S. & Kay, T. W. H. (2003). Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation. IMMUNITY, 18 (4), pp.475-487. https://doi.org/10.1016/S1074-7613(03)00078-5.
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C1 - Journal Articles Refereed
To determine the tissue-specific functions of SOCS-1, mice were generated in which the SOCS-1 gene could be deleted in individual tissues. A reporter gene of SOCS-1 promoter activity was also inserted. Using the reporter, high SOCS-1 expression was found at the CD4(+)CD8(+) stage in thymocyte development. To investigate the function of this expression, the SOCS-1 gene was specifically deleted throughout the thymocyte/T/NKT cell compartment. Unlike SOCS-1(-/-) mice, these mice did not develop lethal multiorgan inflammation but developed multiple lymphoid abnormalities, including enhanced differentiation of thymocytes toward CD8(+) T cells and very high percentages of peripheral CD8(+) T cells with a memory phenotype (CD44(hi)CD25(lo)CD69(lo)). These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines.
KeywordsCellular Immunology; Immune System and Allergy
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