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dc.contributor.authorChong, MMW
dc.contributor.authorCornish, AL
dc.contributor.authorDarwiche, R
dc.contributor.authorStanley, EG
dc.contributor.authorPurton, JF
dc.contributor.authorGodfrey, DI
dc.contributor.authorHilton, DJ
dc.contributor.authorStarr, R
dc.contributor.authorAlexander, WS
dc.contributor.authorKay, TWH
dc.date.available2014-05-21T19:30:20Z
dc.date.issued2003-04-01
dc.identifierpii: S1074-7613(03)00078-5
dc.identifier.citationChong, M. M. W., Cornish, A. L., Darwiche, R., Stanley, E. G., Purton, J. F., Godfrey, D. I., Hilton, D. J., Starr, R., Alexander, W. S. & Kay, T. W. H. (2003). Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation. IMMUNITY, 18 (4), pp.475-487. https://doi.org/10.1016/S1074-7613(03)00078-5.
dc.identifier.issn1074-7613
dc.identifier.urihttp://hdl.handle.net/11343/26381
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractTo determine the tissue-specific functions of SOCS-1, mice were generated in which the SOCS-1 gene could be deleted in individual tissues. A reporter gene of SOCS-1 promoter activity was also inserted. Using the reporter, high SOCS-1 expression was found at the CD4(+)CD8(+) stage in thymocyte development. To investigate the function of this expression, the SOCS-1 gene was specifically deleted throughout the thymocyte/T/NKT cell compartment. Unlike SOCS-1(-/-) mice, these mice did not develop lethal multiorgan inflammation but developed multiple lymphoid abnormalities, including enhanced differentiation of thymocytes toward CD8(+) T cells and very high percentages of peripheral CD8(+) T cells with a memory phenotype (CD44(hi)CD25(lo)CD69(lo)). These phenotypes were found to correlate with hypersensitivity to the gamma-common family of cytokines.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherCELL PRESS
dc.subjectCellular Immunology; Immune System and Allergy
dc.titleSuppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8(+) T cell differentiation
dc.typeJournal Article
dc.identifier.doi10.1016/S1074-7613(03)00078-5
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentMedicine - St Vincent'S Hospital
melbourne.source.titleIMMUNITY
melbourne.source.volume18
melbourne.source.issue4
melbourne.source.pages475-487
dc.research.coderfcd320202
dc.research.codeseo1998730102
melbourne.publicationid22037
melbourne.elementsid260105
melbourne.contributor.authorGodfrey, Dale
melbourne.contributor.authorKay, Thomas
melbourne.contributor.authorCornish, Ann
melbourne.contributor.authorChong, Mark
melbourne.contributor.authorStanley, Edouard
dc.identifier.eissn1097-4180
melbourne.accessrightsThis item is currently not available from this repository


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