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dc.contributor.authorJenkins, AJ
dc.contributor.authorMcBride, JD
dc.contributor.authorJanuszewski, AS
dc.contributor.authorKarschimkus, CS
dc.contributor.authorZhang, B
dc.contributor.authorO'Neal, DN
dc.contributor.authorNelson, CL
dc.contributor.authorChung, JS
dc.contributor.authorHarper, CA
dc.contributor.authorLyons, TJ
dc.contributor.authorMa, J-X
dc.date.accessioned2021-02-21T23:49:41Z
dc.date.available2021-02-21T23:49:41Z
dc.date.issued2010-09-22
dc.identifierpii: 2040-2384-2-19
dc.identifier.citationJenkins, A. J., McBride, J. D., Januszewski, A. S., Karschimkus, C. S., Zhang, B., O'Neal, D. N., Nelson, C. L., Chung, J. S., Harper, C. A., Lyons, T. J. & Ma, J. -X. (2010). Increased serum kallistatin levels in type 1 diabetes patients with vascular complications.. J Angiogenes Res, 2 (1), pp.19-. https://doi.org/10.1186/2040-2384-2-19.
dc.identifier.issn2040-2384
dc.identifier.urihttp://hdl.handle.net/11343/263886
dc.description.abstractBACKGROUND: Kallistatin, a serpin widely produced throughout the body, has vasodilatory, anti-angiogenic, anti-oxidant, and anti-inflammatory effects. Effects of diabetes and its vascular complications on serum kallistatin levels are unknown. METHODS: Serum kallistatin was quantified by ELISA in a cross-sectional study of 116 Type 1 diabetic patients (including 50 with and 66 without complications) and 29 non-diabetic controls, and related to clinical status and measures of oxidative stress and inflammation. RESULTS: Kallistatin levels (mean(SD)) were increased in diabetic vs. control subjects (12.6(4.2) vs. 10.3(2.8) μg/ml, p = 0.007), and differed between diabetic patients with complications (13.4(4.9) μg/ml), complication-free patients (12.1(3.7) μg/ml), and controls; ANOVA, p = 0.007. Levels were higher in diabetic patients with complications vs. controls, p = 0.01, but did not differ between complication-free diabetic patients and controls, p > 0.05. On univariate analyses, in diabetes, kallistatin correlated with renal dysfunction (cystatin C, r = 0.28, p = 0.004; urinary albumin/creatinine, r = 0.34, p = 0.001; serum creatinine, r = 0.23, p = 0.01; serum urea, r = 0.33, p = 0.001; GFR, r = -0.25, p = 0.009), total cholesterol (r = 0.28, p = 0.004); LDL-cholesterol (r = 0.21, p = 0.03); gamma-glutamyltransferase (GGT) (r = 0.27, p = 0.04), and small artery elasticity, r = -0.23, p = 0.02, but not with HbA1c, other lipids, oxidative stress or inflammation. In diabetes, geometric mean (95%CI) kallistatin levels adjusted for covariates, including renal dysfunction, were higher in those with vs. without hypertension (13.6 (12.3-14.9) vs. 11.8 (10.5-13.0) μg/ml, p = 0.03). Statistically independent determinants of kallistatin levels in diabetes were age, serum urea, total cholesterol, SAE and GGT, adjusted r2 = 0.24, p < 0.00001. CONCLUSIONS: Serum kallistatin levels are increased in Type 1 diabetic patients with microvascular complications and with hypertension, and correlate with renal and vascular dysfunction.
dc.languageeng
dc.publisherPubliverse Online S.R.L
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleIncreased serum kallistatin levels in type 1 diabetes patients with vascular complications.
dc.typeJournal Article
dc.identifier.doi10.1186/2040-2384-2-19
melbourne.affiliation.departmentClinical School (Royal Melbourne Hospital)
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleJournal of angiogenesis research
melbourne.source.volume2
melbourne.source.issue1
melbourne.source.pages19-
dc.rights.licenseCC BY
melbourne.elementsid328434
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954956
melbourne.contributor.authorJenkins, Alicia
melbourne.contributor.authorKARSCHIMKUS, CONNIE
melbourne.contributor.authorO'Neal, David
melbourne.contributor.authorHarper, Colin
melbourne.contributor.authorJanuszewski, Andrzej
melbourne.contributor.authorNELSON, CRAIG
melbourne.contributor.authorCHUNG, SHIMIN
dc.identifier.eissn2040-2384
melbourne.accessrightsOpen Access


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