High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence
Author
Bradshaw, CS; Morton, AN; Hocking, J; Garland, SM; Morris, MB; Moss, LM; Horvath, LB; Kuzevska, I; Fairley, CKDate
2006-06-01Source Title
JOURNAL OF INFECTIOUS DISEASESPublisher
OXFORD UNIV PRESS INCUniversity of Melbourne Author/s
BRADSHAW, CATRIONA SUSAN; Hocking, Jane; Wark, Suzanne; HORVATH, LEONIE; Kuzevska, Irene; Fairley, ChristopherAffiliation
Population HealthMetadata
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Journal ArticleCitations
Bradshaw, C. S., Morton, A. N., Hocking, J., Garland, S. M., Morris, M. B., Moss, L. M., Horvath, L. B., Kuzevska, I. & Fairley, C. K. (2006). High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. JOURNAL OF INFECTIOUS DISEASES, 193 (11), pp.1478-1486. https://doi.org/10.1086/503780.Access Status
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10.1086/503780Description
C1 - Journal Articles Refereed
Abstract
BACKGROUND: We wished to determine recurrences of bacterial vaginosis (BV) after treatment over the course of 12 months and to establish factors associated with recurrence. METHODS: Women with symptomatic BV (a Nugent score [NS] of 7-10 or of 4-6 with >or=3 Amsel criteria) were enrolled. BV was treated with 400 mg of oral metronidazole twice a day for 7 days. Participants completed a questionnaire and vaginal swabs were collected at 1, 3, 6, and 12 months; the study end point was an NS of 7-10. RESULTS: A total of 121 (87%) women with an NS of 7-10 and 18 (13%) with an NS of 4-6 and >or=3 Amsel criteria were enrolled; 130 (94%) returned >or=1 vaginal samples. Sixty-eight women (58% [95% confidence interval {CI}, 49%-66%]) had a recurrence of BV (NS 7-10), and 84 (69% [95% CI, 61%-77%]) had a recurrence of abnormal vaginal flora (NS 4-10) by 12 months. A past history of BV, a regular sex partner throughout the study, and female sex partners were significantly associated with recurrence of BV and abnormal vaginal flora by multivariate analysis; the use of hormonal contraception had a negative association with recurrence. CONCLUSION: Current recommended treatment is not preventing the recurrence of BV or abnormal vaginal flora in the majority of women; factors associated with recurrence support a possible role for sexual transmission in the pathogenesis of recurrent BV.
Keywords
Preventive Medicine; Women's Health; Preventive MedicineExport Reference in RIS Format
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